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Colin F. Fletcher
Researcher at Novartis Foundation
Publications - 1
Citations - 250
Colin F. Fletcher is an academic researcher from Novartis Foundation. The author has contributed to research in topics: Proteases & Ubiquitin. The author has an hindex of 1, co-authored 1 publications receiving 243 citations.
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Synaptic defects in ataxia mice result from a mutation in Usp14 , encoding a ubiquitin-specific protease
Scott M. Wilson,Bula J. Bhattacharyya,Rivka A. Rachel,Vincenzo Coppola,Lino Tessarollo,Deborah B. Householder,Colin F. Fletcher,Richard J. Miller,Neal G. Copeland,Nancy A. Jenkins +9 more
TL;DR: It is shown that ax encodes ubiquitin-specific protease 14 (Usp14), and expression of Usp14 is significantly altered in axJ/axJ mice as a result of the insertion of an intracisternal-A particle (IAP) into intron 5 of USp14.