C
Colin M. Clay
Researcher at Colorado State University
Publications - 78
Citations - 4095
Colin M. Clay is an academic researcher from Colorado State University. The author has contributed to research in topics: Gonadotropic cell & Gonadotropin-releasing hormone. The author has an hindex of 38, co-authored 77 publications receiving 3955 citations. Previous affiliations of Colin M. Clay include Case Western Reserve University.
Papers
More filters
Journal ArticleDOI
KiSS-1 messenger ribonucleic acid expression in the hypothalamus of the ewe is regulated by sex steroids and season.
TL;DR: It is concluded that KiSS-1 expression in the ARC of the ewe brain is negatively regulated by chronic levels of E and P, suggesting that both steroids may exert negative feedback control on GnRH secretion through altered kisspeptin signaling.
Journal ArticleDOI
Targeted overexpression of luteinizing hormone in transgenic mice leads to infertility, polycystic ovaries, and ovarian tumors.
TL;DR: The pathology observed demonstrates a direct association between abnormal secretion of LH and infertility and underscores the utility of the transgenic model for studying how excess LH leads to cyst formation, ovarian tumorigenesis, and infertility.
Journal ArticleDOI
Molecular Cloning of the Ovine Growth/Differentiation Factor-9 Gene and Expression of Growth/Differentiation Factor-9 in Ovine and Bovine Ovaries
TL;DR: The observed timing and pattern of GDF-9 expression in oocytes of domestic ruminants is consistent with a role for GDF9 in the initiation and maintenance of folliculogenesis in these species, and supports the general concept that early stages of follicular growth and development are regulated by intraovarian factors.
Journal ArticleDOI
Elevated KiSS-1 expression in the arcuate nucleus prior to the cyclic preovulatory gonadotrophin-releasing hormone/lutenising hormone surge in the ewe suggests a stimulatory role for kisspeptin in oestrogen-positive feedback.
TL;DR: Gen expression of KiSS‐1 in the arcuate nucleus (ARC) across the ovine oestrous cycle is quantified and an increase in the caudal division of the ARC during the preovulatory period is demonstrated, suggesting that kisspeptins are involved in the generation of the prevulatory GnRH and luteinising hormone surge.
Journal ArticleDOI
Constitutive Localization of the Gonadotropin-releasing Hormone (GnRH) Receptor to Low Density Membrane Microdomains Is Necessary for GnRH Signaling to ERK
Amy M. Navratil,Stuart P. Bliss,Kathie A. Berghorn,James M. Haughian,Todd A. Farmerie,James K. Graham,Colin M. Clay,Mark S. Roberson +7 more
TL;DR: The organization of the GnRHR into low density membrane microdomains appears critical in mediating GnRH induced intracellular signaling.