Colin R. Green

TL;DR: It is concluded that peptide-based investigations have raised several new opportunities for interfering with connexins and their channels that may soon allow preservation of gap junction communication, inhibition of hemichannel opening, and mitigation of inflammatory signaling.

TL;DR: Conventional eye drops can result in poor drug bioavailability due to the unique ocular anatomy and physiology, but formulations based on gellan gum and carrageenan demonstrated a remarkable increase in viscosity, pseudoplasticity and hardness upon addition of Ca(2+) and K(+) respectively.

TL;DR: The structures of 13 variants of invertebrate septate junction are reviewed on the basis offreeze-fracture, lanthanum tracer and thin-section studies, and a theory is put forward suggesting that in evolution a change from the septates to the tight junction could simply involve a modification of a ‘membrane spacing factor’, which allows the membranes of adjacent cells to come together at intervals.

TL;DR: After wounding, the capacity for epithelial cell proliferative and migration appears to be as active in the central cornea as in the periphery/limbus, and central and peripheral epithelial recovery remains equal even after ablation of the limbus.

TL;DR: The relationship between BG and gap junction connexin 43 mediated endothelial cell behavior is revealed and one of the possible mechanisms through which BG stimulates wound healing is elucidated.