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Cong Shen
Researcher at Sun Yat-sen University
Publications - 23
Citations - 721
Cong Shen is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: MCR-1 & Colistin. The author has an hindex of 10, co-authored 21 publications receiving 343 citations. Previous affiliations of Cong Shen include Guangzhou University of Chinese Medicine.
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Journal ArticleDOI
Colistin and its role in the Era of antibiotic resistance: an extended review(2000–2019)
Mohamed Abd El-Gawad El-Sayed Ahmed,Mohamed Abd El-Gawad El-Sayed Ahmed,Lan Lan Zhong,Cong Shen,Yongqiang Yang,Yohei Doi,Yohei Doi,Guo-Bao Tian +7 more
TL;DR: This review intends to discuss the progress over the last two decades in understanding the alternative colistin mechanisms of action and different strategies used by bacteria to develop resistance againstcolistin, besides providing an update about what is previously recognized and what is novel concerning colistsin resistance.
Journal ArticleDOI
Dynamics of mcr-1 prevalence and mcr-1-positive Escherichia coli after the cessation of colistin use as a feed additive for animals in China: A prospective cross-sectional and whole genome sequencing based molecular epidemiological study
Cong Shen,Lan-Lan Zhong,Yongqiang Yang,Yohei Doi,Yohei Doi,David L. Paterson,Nicole Stoesser,Furong Ma,Mohamed Abd El-Gawad El-Sayed Ahmed,Mohamed Abd El-Gawad El-Sayed Ahmed,Siyuan Feng,Songying Huang,Hongyu Li,Xi Huang,Xin Wen,Zihan Zhao,Minmin Lin,Guanping Chen,Wanfei Liang,Yingjian Liang,Yong Xia,Min Dai,Ding Qiang Chen,Liyan Zhang,Kang Liao,Guo-Bao Tian +25 more
TL;DR: A rapid, ecosystem-wide, decline in mcr-1 was observed after the use of colistin in animal feed was banned, with associated genetic changes in MCRPEC.
Journal ArticleDOI
High rates of human fecal carriage of mcr-1-positive multidrug-resistant Enterobacteriaceae emerge in China in association with successful plasmid families.
Lan Lan Zhong,Hang T. T. Phan,Cong Shen,Karina Doris Vihta,Anna E. Sheppard,Xi Huang,Kun Jiao Zeng,Hongyu Li,Xue Fei Zhang,Sandip Patil,Derrick W. Crook,A. Sarah Walker,Yong Xing,Jia lin Lin,Lian Qiang Feng,Yohei Doi,Yong Xia,Nicole Stoesser,Guo-Bao Tian +18 more
TL;DR: The high prevalence of mcr-1 in multidrug-resistant E. coli colonizing humans is a clinical threat; diverse genetic mechanisms (strains/plasmids/insertion sequences) have contributed to the dissemination of mCr-1, and will facilitate its persistence.
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Spread of MCR-3 Colistin Resistance in China: An Epidemiological, Genomic and Mechanistic Study
Yongchang Xu,Lan-Lan Zhong,Swaminath Srinivas,Jian Sun,Man Huang,David L. Paterson,Sheng Lei,Jingxia Lin,Xin Li,Zichen Tang,Siyuan Feng,Cong Shen,Guo-Bao Tian,Youjun Feng,Youjun Feng +14 more
TL;DR: It is proposed that MCR-3 uses a possible “ping-pong” mechanism to transfer the moiety of PEA from its donor PE to the 1(or 4′)-phosphate of lipid A via an adduct of M CR-3-bound PEA, a conserved PE-lipid recognizing cavity prerequisite for its enzymatic catalysis and its resultant phenotypic resistance to colistin.
Journal ArticleDOI
Identification of a Novel Plasmid Carrying mcr-4.3 in an Acinetobacter baumannii Strain in China.
Furong Ma,Cong Shen,Xiaobin Zheng,Yan Liu,Hongtao Chen,Lan-Lan Zhong,Yingjian Liang,Kang Liao,Yong Xia,Guo-Bao Tian,Yongqiang Yang +10 more
TL;DR: Data indicate that mcr-4.3 was captured by an A. baumannii-original plasmid via horizontal gene transfer, and pAB18PR065 harbors two copies of type II toxin-antitoxin systems, which are functional in plasmids stabilization and maintenance.