S
S. Robert Snodgrass
Researcher at University of California, Los Angeles
Publications - 21
Citations - 2021
S. Robert Snodgrass is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Age of onset & Huntington's disease. The author has an hindex of 12, co-authored 21 publications receiving 1831 citations. Previous affiliations of S. Robert Snodgrass include University of Southern California.
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Journal ArticleDOI
Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset
Nancy S. Wexler,Judith Lorimer,Julie Porter,Fidela Gomez,Carol Moskowitz,Edith Shackell,Karen Marder,Penchaszadeh Gk,Simone A. Roberts,Javier Gayán,Denise Brocklebank,Stacey S. Cherny,Lon R. Cardon,Jacqueline Gray,Stephen R. Dlouhy,Sandra Wiktorski,Marion E. Hodes,P. Michael Conneally,J. B. Penney,James F. Gusella,Jang Ho Cha,Michael C. Irizarry,Diana Rosas,Steven M. Hersch,Zane R. Hollingsworth,Marcy E. MacDonald,Anne B. Young,J. Michael Andresen,David E. Housman,Margot de Young,Ernesto Bonilla,Theresa Stillings,Américo Negrette,S. Robert Snodgrass,Maria Dolores Martinez-Jaurrieta,Maria A. Ramos-Arroyo,Jacqueline Bickham,Juan Sanchez Ramos,Frederick J. Marshall,Ira Shoulson,Gustavo Rey,Andrew Feigin,Norman Arnheim,Amarilis Acevedo-Cruz,Leticia Acosta,Jose Alvir,Kenneth H. Fischbeck,Leslie M. Thompson,Angela Young,Leon S. Dure,Christopher J. O'Brien,Jane S. Paulsen,Adam M. Brickman,Denise Krch,Shelley Peery,Penelope Hogarth,Donald S. Higgins,Bernhard Landwehrmeyeri +57 more
TL;DR: A model estimated the components of additive genetic, shared environment, and nonshared environment variances confirming that approximately 40% of the variance remaining in onset age is attributable to genes other than the HD gene and 60% is environmental.
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Homozygotes for Huntington's disease
Nancy S. Wexler,Nancy S. Wexler,Anne B. Young,Rudolph E. Tanzi,Helen Travers,Simon Starosta-Rubinstein,John B. Penney,S. Robert Snodgrass,Ira Shoulson,Fidela Gomez,Maria A. Ramos Arroyo,Penchaszadeh Gk,Penchaszadeh Gk,Humberto Moreno,Kerin T. Gibbons,Ann Faryniarz,Wendy Hobbs,Mary Anne Anderson,Ernesto Bonilla,P. Michael Conneally,James F. Gusella +20 more
TL;DR: HD appears to be the first human disease of genetically documented homozygosity that displays complete phenotypic dominance, indicating that the normal allele may play a role in ameliorating the disease process.
Journal ArticleDOI
A balanced view of the cerebrospinal fluid composition and functions: Focus on adult humans
TL;DR: The CP/CSF, the third circulation, performs many functions comparable to the kidney including nourishing the brain and contributing to a stable internal milieu for the brain.
Journal ArticleDOI
Huntington's disease in venezuela: 7 years of follow‐up on symptomatic and asymptomatic individuals
John B. Penney,Anne B. Young,Ira Shoulson,Simon Starosta-Rubenstein,S. Robert Snodgrass,Juan Sanchez-Ramos,Maria A. Ramos-Arroyo,Fidela Gomez,Penchaszadeh Gk,Jose Alvir,Jesús Esteves,Iris DeQuiroz,Nelson Marsol,Humberto Moreno,P. Michael Conneally,Ernesto Bonilla,Nancy S. Wexler +16 more
TL;DR: Persons symptomatic and at risk for Huntington's disease from a large extended family in the state of Zulia, Venezuela, have been followed prospectively for 7 years and suggest that there is not a discrete age of onset but rather a prolonged period of time during which symptoms unfold.
Journal ArticleDOI
A balanced view of choroid plexus structure and function: Focus on adult humans.
TL;DR: Clinical support for this CP-CSF model comes from neurosurgical procedures to remove lateral ventricle CPs in hydrocephalic children to reduce CSF formation, thereby relieving elevated ICP and multiple transport and secretory functions in CP support CSF homeostasis and fluid dynamics essential for brain function.