Conxita Jacobs-Cachá

TL;DR: Male gender is associated with worse CKD progression and this fact may be ascribed to sex hormone, although male hormones exert a deleterious effect in terms of increasing oxidative stress, activating RAS system, and worsening fibrosis within the damaged kidney.

TL;DR: The importance of the MMPs within the kidney and their modifications at the circulation, kidney and urine in patients with DKD is focused and the most important studies performed in experimental models of diabetes in terms of M MPs levels, renal expression and its down-regulation effect are covered.

TL;DR: Urinary ApoA‐Ib is associated with relapses in idiopathic FSGS and warrants additional investigation to determine its usefulness as biomarker of relapse following transplantation.

TL;DR: The description of the new DN rodent models is focused on and an overview of the available methods for renal phenotyping is provided, to characterize the pathways that are involved in DN, identify risk biomarkers and prevent kidney failure in diabetic patients.

TL;DR: Clinical experience suggests that SGLT2i safety management may in part mirror renin–angiotensin blockade safety management in patients with overt DKD, and proposed clinical steps for maximizing the safety of SGLt2i in DKD patients on other antidiabetic, BP or diuretic medication are proposed.