Coral Omene

TL;DR: The results strongly suggest that CAPE inhibits MDA-231 and MCF-7 human breast cancer growth via its apoptotic effects, and modulation of NF-κB, the cell cycle, and angiogenesis.

TL;DR: It is suggested that CAPE causes pronounced changes in bCSC characteristics manifested by inhibition of self renewal, progenitor formation, clonal growth in soft agar, and concurrent significant decrease in CD44 content, all signs of decreased malignancy potential.

TL;DR: Everolimus-carboplatin was efficacious in metastatic TNBC and dose limiting hematological toxicity was observed when AUC5/6 of carboplatin is combined with everolimus, however, carboplarin AUC 4 was well tolerated in combination with Everolimus with continuing responses.

TL;DR: Interestingly, propolis, when normalized for CAPE content, appears to be more potent than CAPE alone similarly to the greater effects of complete foods than isolated components, which provide a potential mechanistic basis for one of the oldest naturopathic agents used in medicine and cancer treatment.

TL;DR: In this paper, the authors explore the preclinical and pharmacological differences between the three approved agents and help understand the benefits seen with these agents in certain subgroups of patients with metastatic HR positive breast cancer.