Showing papers in "Cancer Letters in 2011"

TL;DR: Celastrol's ability to modulate the expression of pro-inflammatory cytokines, MHC II, HO-1, iNOS, NF-κB, Notch- 1, AKT/mTOR, CXCR4, TRAIL receptors DR4 and DR5, CHOP, JNK, VEGF, adhesion molecules, proteasome activity, potassium channels, and heat shock response has been reported.

TL;DR: This mini-review summaries the diverse influences of galectin-3 on cancer cell behaviours with particular emphasis on its role in tumorigenesis and metastasis.

TL;DR: The results suggest that the activation of Notch-1 signaling contributes to the acquisition of EMT phenotype, which is in part mediated through the regulation of miR-200b and CSC self-renewal capacity, and these processes could be attenuated by genistein treatment.

TL;DR: The findings suggest that CPO can interfere with multiple signaling cascades involved in tumorigenesis and used as a potential therapeutic candidate for both the prevention and treatment of cancer.

TL;DR: The performance of newly synthesized chitosan-coated silver nanotriangles (Chit-AgNTs) with strong resonances in near-infrared (NIR) to operate as photothermal agents against a line of human non-small lung cancer cells is reported.

TL;DR: This mini-review reports on the pre-clinical studies that have been performed to date with carnosol describing mechanistic, efficacy, and safety/tolerability studies as a cancer chemoprevention and anti-cancer agent.

TL;DR: It is shown that Rh2 exhibited significantly more potent cell death activity than the ginsenoside Rg3 in HCT116 and SW480 colorectal cancer cells, suggesting that the anti-cancer effect of Rh2 can be enhanced by antioxidants.

TL;DR: The data indicate that CAFs play a vital role in ovarian cancer progression and metastasis and targeting CAFs as a therapeutic strategy against ovarian cancer is an intriguing concept that needs further study.

TL;DR: The emerging relationship between the microbiota and development of colorectal cancer is discussed as well as evidence that microbial manipulation (probiotic, prebiotic) impacts disease development is presented.

TL;DR: Investigating the methylation profiles of non-small cell lung cancer in the Chinese population indicated that methylated alteration of multiple genes plays an important role in NSCLC pathogenesis and a panel of candidate epigenetic biomarkers forNSCLC detection in theChinese population was identified.

TL;DR: Results demonstrated that combination of Ad-miR122 with chemotherapeutic agents inhibited HCC cell growth by inducing G2/M arrest and that this arrest is associated, at least in part, with reduced expression of MDR related genes and Cyclin B1.

TL;DR: Eradication of H. pylori with combination antibiotic therapy cures most cases of gastric lymphoma and slows progression to gastric adenocarcinoma.

TL;DR: The results strongly suggest that CAPE inhibits MDA-231 and MCF-7 human breast cancer growth via its apoptotic effects, and modulation of NF-κB, the cell cycle, and angiogenesis.

TL;DR: Findings suggest that paclitaxel-elicited autophagic response plays a protective role that impedes the eventual cell death, and inhibition of autophagy could be an adjunctive strategy for enhancing chemotherapeutic effect of pac litaxel as an antitumor agent.

TL;DR: The current state of knowledge on KSHV epidemiology and KS pathogenesis is surveyed and therapeutic opportunities in both the developed and developing world are highlighted.

TL;DR: Findings suggest that miR-34a targeting the Sirt1 and E2F3 genes could negatively regulate, at least in part, the resistance to 5-FU in human colorectal cancer DLD-1 cells.

TL;DR: The methods currently being used to develop miRNA-based cancer therapeutics are examined, and the limitations halting further progress are also discussed.

TL;DR: Understanding the specific viral associations in selected lymphoproliferative disorders, and the insights into the molecular mechanisms of viral oncogenesis, will lead to better treatments for these frequently devastating diseases.

TL;DR: This study identifies a new set of ZEB-regulated genes in human lung cancer cells and supports the hypothesis that ZEB1 and ZEB2 are key regulators of the EMT process in this disease.

TL;DR: It is demonstrated that some autophagic pathways play dual roles in cancer, and further elucidate the intricate relationship between apoptosis and autophagy.

TL;DR: The results indicated that LCA was the most cytotoxic licorice compound of those tested, and it inhibited gastric cancer cells growth in a dose-dependent manner, with an IC50 value of approximately 40μM.

TL;DR: It is identified that salinomycin is an effective inhibitor of osteosarcoma stem cells, supporting the use of salinomecin for elimination of osteOSarcomA stem cells and implying a need for further clinical evaluation.

TL;DR: T-DM1 showed a promising anti-tumor effect in HER2-positive gastric cancer cell lines in vitro and in vivo, even in tumors which had developed resistance to trastuzumab.

TL;DR: This review briefly described the classification of MAGE family members and their expression pattern in cancer, the mechanism of MAGES activation and the functions of Mage family members in cell cycle progression and apoptosis, and what is known of immunotherapy targeting MAGEfamily.

TL;DR: It is demonstrated that the flavonoid myricetin induced pancreatic cancer cell death in vitro via apoptosis, and caused a decrease in PI3 kinase activity, and in vivo, treatment of orthotopic pancreatic tumors with myricets resulted in tumor regression and decreased metastatic spread.

TL;DR: Of the analogues tested, 8-hydroxy-5-nitroquinoline (NQ) was the most toxic, with an IC(50) that was five to ten fold lower than that of other congeners, and its activity was enhanced by copper, but not zinc, and the use of a zinc-sensitive fluorophore showed that unlike clioquinol, NQ is not a zinc ionophore.

TL;DR: It is suggested that BRAF mutations are of pathogenetic significance in wild type GISTs and the PI3K pathway should be assessed in future studies.

TL;DR: Progress in defining mechanisms that may link HBV and HCV infections to the development of HCC is summarized, the challenges of directly defining the processes that underlie HBV- andHCV-associated HCC are discussed, and areas that remain to be explored are described.

TL;DR: Findings suggest that the chemically-modified synthetic miR-143 functions as a tumor suppressor in T24 cells by targeting ERK5 and/or Akt.

TL;DR: AGR2 protein expression induces metastasis, acts as a p53 tumor suppressor inhibitor and survival factor, participates directly in neoplastic transformation and is involved in drug resistance.