C
Cordula Hirsch
Researcher at Swiss Federal Laboratories for Materials Science and Technology
Publications - 40
Citations - 1473
Cordula Hirsch is an academic researcher from Swiss Federal Laboratories for Materials Science and Technology. The author has contributed to research in topics: Genotoxicity & Chemistry. The author has an hindex of 18, co-authored 36 publications receiving 1115 citations. Previous affiliations of Cordula Hirsch include University of St. Gallen.
Papers
More filters
Journal ArticleDOI
Effects of carbon nanotubes on primary neurons and glial cells.
Larisa L. Belyanskaya,Stefan Weigel,Stefan Weigel,Cordula Hirsch,Ursina Tobler,Harald F. Krug,Peter Wick +6 more
TL;DR: It is found that single-walled CNTs with different degrees of agglomeration reduce the amount of glial cells in both peripheral nervous system and central nervous system derived cultures, and if SWCNTs can enter the nervous system at sufficiently high concentrations, it is likely that adverse effects onglial cells and neurons might occur.
Journal ArticleDOI
In vitro mechanistic study towards a better understanding of ZnO nanoparticle toxicity
Tina Buerki-Thurnherr,Lisong Xiao,Liliane Diener,Osman Arslan,Cordula Hirsch,Xenia Maeder-Althaus,Kathrin Grieder,Bruno Wampfler,Sanjay Mathur,Peter Wick,Harald F. Krug +10 more
TL;DR: It is demonstrated that ZnO-induced Jurkat cell death is largely an ionic effect involving the extracellular release of high amounts of Zn(II), their rapid uptake by the cells and the induction of a caspase-independent alternative apoptosis pathway that is independent of the formation of ROS.
Journal ArticleDOI
C60 fullerene: a powerful antioxidant or a damaging agent? The importance of an in-depth material characterization prior to toxicity assays.
TL;DR: It is demonstrated that water-soluble side products which were formed in THF nC(60) suspension were responsible for the observed acute toxic effects, whereas fullerenes themselves had no negative effect regardless of the preparative route on either A549 cell in vitro or D. magna in vivo.
Journal ArticleDOI
In Vitro Research Reproducibility: Keeping Up High Standards.
TL;DR: A selection of the most susceptible steps of everyday in vitro cell culture routines that have the potential to influence cell quality and recommend practices to minimize the likelihood of poor cell quality impairing reproducibility with modest investment of time and resources is compiled.
Journal ArticleDOI
Comparability of in vitro tests for bioactive nanoparticles: a common assay to detect reactive oxygen species as an example.
TL;DR: It is believed that using 3-morpholinosydnonimine hydrochloride (Sin-1) as a ROS inducer in the DCF assay is feasible only qualitatively, however, a quantitative measurement of the absolute amount of ROS produced and a quantitative comparison between experiments is (at the moment) impossible.