C
Corina Sarmiento
Researcher at Yeshiva University
Publications - 7
Citations - 1204
Corina Sarmiento is an academic researcher from Yeshiva University. The author has contributed to research in topics: Actin & Invadopodia. The author has an hindex of 7, co-authored 7 publications receiving 1136 citations. Previous affiliations of Corina Sarmiento include Albert Einstein College of Medicine.
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Journal ArticleDOI
Molecular mechanisms of invadopodium formation the role of the N-WASP–Arp2/3 complex pathway and cofilin
Hideki Yamaguchi,Mike Lorenz,Stephan J. Kempiak,Corina Sarmiento,Salvatore J. Coniglio,Marc Symons,Jeffrey E. Segall,Robert J. Eddy,Hiroaki Miki,Tadaomi Takenawa,John S. Condeelis +10 more
TL;DR: Results indicate that EGF receptor signaling regulatesInvadopodium formation through the N-WASP–Arp2/3 pathway and cofilin is necessary for the stabilization and maturation of invadopodia.
Journal ArticleDOI
Cofilin determines the migration behavior and turning frequency of metastatic cancer cells
Mazen Sidani,Deborah Wessels,Ghassan Mouneimne,Mousumi Ghosh,Sumanta Goswami,Corina Sarmiento,Weigang Wang,Spencer Kuhl,Mirvat El-Sibai,Jonathan M. Backer,Robert J. Eddy,David R. Soll,John S. Condeelis +12 more
TL;DR: The suppression of cofilin expression in MTLn3 cells (an apolar randomly moving amoeboid metastatic tumor cell) caused them to extend protrusions from only one pole, elongate, and move rectilinearly, demonstrating that to chemotax efficiently, a cell must be able to respond to Chemotactic stimulation at any region on its surface.
Journal ArticleDOI
WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells.
Corina Sarmiento,Weigang Wang,Athanassios Dovas,Hideki Yamaguchi,Mazen Sidani,Mirvat El-Sibai,Vera DesMarais,Holly A. Holman,Susan M. Kitchen,Jonathan M. Backer,Art Alberts,John S. Condeelis +11 more
TL;DR: Data show that coordinate regulation between the WASP family and mDia proteins controls the balance between lamellar and lamellipodial protrusion activity.
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N-WASP and cortactin are involved in invadopodium-dependent chemotaxis to EGF in breast tumor cells.
Vera DesMarais,Hideki Yamaguchi,Matthew G. Oser,Lilian Soon,Ghassan Mouneimne,Corina Sarmiento,Robert J. Eddy,John S. Condeelis +7 more
TL;DR: In this paper, invadopodia formation on glass requires N-WASP and cortactin but not microtubules, and depletion of either protein inhibits chemotaxis of cells towards EGF.
Journal ArticleDOI
A neural Wiskott-Aldrich Syndrome protein-mediated pathway for localized activation of actin polymerization that is regulated by cortactin
Stephan J. Kempiak,Hideki Yamaguchi,Corina Sarmiento,Mazen Sidani,Mousumi Ghosh,Robert J. Eddy,Vera DesMarais,Michael Way,John S. Condeelis,Jeffrey E. Segall +9 more
TL;DR: It is shown that the actin polymerization is dependent upon activation of the Arp2/3 complex by neural Wiskott-Aldrich Syndrome protein (N-WASP) via Grb2 and Nck2 and that cortactin can restrict N-WasP localization around EGF-bead-induced protrusions.