J
John S. Condeelis
Researcher at Albert Einstein College of Medicine
Publications - 397
Citations - 45033
John S. Condeelis is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Metastasis & Tumor microenvironment. The author has an hindex of 110, co-authored 369 publications receiving 40937 citations. Previous affiliations of John S. Condeelis include Yeshiva University & Montefiore Medical Center.
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Journal ArticleDOI
Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis
TL;DR: Macrophages within the tumor microenvironment facilitate angiogenesis and extracellular-matrix breakdown and remodeling and promote tumor cell motility and are an important drug target for cancer therapy.
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A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors.
Jeffrey B. Wyckoff,Weigang Wang,Elaine Y. Lin,Yarong Wang,Fiona J. Pixley,E. Richard Stanley,Thomas Graf,Jeffrey W. Pollard,Jeffrey E. Segall,John S. Condeelis +9 more
TL;DR: This work provides the first direct evidence for a synergistic interaction between macrophages and tumor cells during cell migration in vivo and indicates a mechanism for how macrophage may contribute to metastasis.
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Regulation of the actin cytoskeleton in cancer cell migration and invasion
TL;DR: Recent progress on molecular mechanisms of formation of invasive protrusions used by tumor cells, such as lamellipodia and invadopodia, with regard to the functions of key regulatory proteins of the actin cytoskeleton; WASP family proteins, Arp2/3 complex, LIM-kinase, cofilin, and cortactin are summarized.
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Direct Visualization of Macrophage-Assisted Tumor Cell Intravasation in Mammary Tumors
Jeffrey B. Wyckoff,Yarong Wang,Elaine Y. Lin,Jiu Feng Li,Sumanta Goswami,E. Richard Stanley,Jeffrey E. Segall,Jeffrey W. Pollard,John S. Condeelis +8 more
TL;DR: The results show that the interaction between macrophages and tumor cells lying in close proximity defines a microenvironment that is directly involved in the intravasation of cancer cells in mammary tumors.
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Filamins as integrators of cell mechanics and signalling.
Thomas P. Stossel,John S. Condeelis,Lynn Cooley,John H. Hartwig,Angelika A. Noegel,Michael Schleicher,Sandor S. Shapiro +6 more
TL;DR: The history, structure and function ofamins are described, which are large actin-binding proteins that stabilize delicate three-dimensional actin webs and link them to cellular membranes.