C
Cosimo Commisso
Researcher at New York University
Publications - 11
Citations - 3140
Cosimo Commisso is an academic researcher from New York University. The author has contributed to research in topics: Extracellular & Internal medicine. The author has an hindex of 6, co-authored 7 publications receiving 2431 citations.
Papers
More filters
Journal ArticleDOI
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
Cosimo Commisso,Shawn M. Davidson,Rengin G. Soydaner-Azeloglu,Seth J. Parker,Jurre J. Kamphorst,Sean R. Hackett,Elda Grabocka,Michel Nofal,Jeffrey A. Drebin,Craig B. Thompson,Joshua D. Rabinowitz,Christian M. Metallo,Matthew G. Vander Heiden,Matthew G. Vander Heiden,Dafna Bar-Sagi +14 more
TL;DR: In this paper, it was shown that Ras-transformed cells use macropinocytosis to transport extracellular protein into the cell, yielding amino acids including glutamine that can enter central carbon metabolism.
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
Cosimo Commisso,Shawn M. Davidson,Rengin G. Soydaner-Azeloglu,Seth J. Parker,Jurre J. Kamphorst,Sean R. Hackett,Elda Grabocka,Michel Nofal,Jeffrey A. Drebin,Craig B. Thompson,Joshua D. Rabinowitz,Christian M. Metallo,Matthew G. Vander Heiden,Matthew G. Vander Heiden,Dafna Bar-Sagi +14 more
TL;DR: It is shown that Ras-transformed cells use macropinocytosis to transport extracellular protein into the cell, and its pharmacological inhibition compromises the growth of Ras- transformed pancreatic tumour xenografts.
Journal ArticleDOI
Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein
Jurre J. Kamphorst,Michel Nofal,Cosimo Commisso,Sean R. Hackett,Wenyun Lu,Elda Grabocka,Matthew G. Vander Heiden,Matthew G. Vander Heiden,George Miller,Jeffrey A. Drebin,Dafna Bar-Sagi,Craig B. Thompson,Joshua D. Rabinowitz +12 more
TL;DR: In this paper, the authors examined the metabolism of pancreatic ductal adenocarcinoma (PDAC), a poorly vascularized lethal KRAS-driven malignancy.
Journal ArticleDOI
Determining the macropinocytic index of cells through a quantitative image-based assay
TL;DR: A protocol is described for visualizing and quantifying the extent of macropinocytosis in cells both in culture and growing in vivo as tumor xenografts, which can be ascertained within 1–2 d.
Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein
Jurre J. Kamphorst,Michel Nofal,Cosimo Commisso,Sean R. Hackett,Wenyun Lu,Elda Grabocka,M. G. Vander Heiden,George Miller,Jeffrey A. Drebin,Dafna Bar-Sagi,Craig B. Thompson,Joshua D. Rabinowitz +11 more
TL;DR: The findings argue that the scavenging of extracellular proteins is an important mode of nutrient uptake in PDAC, and active macropinocytosis is observed in primary human PDAC specimens.