Rengin G. Soydaner-Azeloglu

TL;DR: In this paper, it was shown that Ras-transformed cells use macropinocytosis to transport extracellular protein into the cell, yielding amino acids including glutamine that can enter central carbon metabolism.

TL;DR: It is shown that Ras-transformed cells use macropinocytosis to transport extracellular protein into the cell, and its pharmacological inhibition compromises the growth of Ras- transformed pancreatic tumour xenografts.

TL;DR: These findings implicate EZH2 in constraining neoplastic progression through homeostatic mechanisms that control pancreatic regeneration and provide insights into the documented link between chronic pancreatic injury and an increased risk for pancreatic cancer.

TL;DR: In this paper, the authors proposed methods of inhibiting both proliferation and survival of cancer cells and for treating a subject having cancer. And they further directed to methods of diagnosing cancer in a subject and identifying cancer therapeutics.

TL;DR: The results, combined with those of earlier studies that probe the role of hydrogen-bond formation in folding and the burial of surface area, reveal that the transition state for NTL9 contains extensive backbone structure and buries a significant fraction of hydrophobicsurface area, but lacks well developed side-chain-side-chain interactions.