C
Christian M. Metallo
Researcher at University of California, San Diego
Publications - 145
Citations - 15999
Christian M. Metallo is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Lipogenesis & Flux (metabolism). The author has an hindex of 50, co-authored 125 publications receiving 11956 citations. Previous affiliations of Christian M. Metallo include Salk Institute for Biological Studies & University of Wisconsin-Madison.
Papers
More filters
Journal ArticleDOI
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
Christian M. Metallo,Paulo A. Gameiro,Eric L. Bell,Katherine R. Mattaini,Juanjuan Yang,Karsten Hiller,Karsten Hiller,Christopher M. Jewell,Zachary R. Johnson,Darrell J. Irvine,Darrell J. Irvine,Leonard Guarente,Joanne K. Kelleher,Matthew G. Vander Heiden,Matthew G. Vander Heiden,Othon Iliopoulos,Gregory Stephanopoulos +16 more
TL;DR: It is shown that human cells use reductive metabolism of α-ketoglutarate to synthesize AcCoA for lipid synthesis and support lipid synthesis in mammalian cells.
Journal ArticleDOI
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
Cosimo Commisso,Shawn M. Davidson,Rengin G. Soydaner-Azeloglu,Seth J. Parker,Jurre J. Kamphorst,Sean R. Hackett,Elda Grabocka,Michel Nofal,Jeffrey A. Drebin,Craig B. Thompson,Joshua D. Rabinowitz,Christian M. Metallo,Matthew G. Vander Heiden,Matthew G. Vander Heiden,Dafna Bar-Sagi +14 more
TL;DR: In this paper, it was shown that Ras-transformed cells use macropinocytosis to transport extracellular protein into the cell, yielding amino acids including glutamine that can enter central carbon metabolism.
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
Cosimo Commisso,Shawn M. Davidson,Rengin G. Soydaner-Azeloglu,Seth J. Parker,Jurre J. Kamphorst,Sean R. Hackett,Elda Grabocka,Michel Nofal,Jeffrey A. Drebin,Craig B. Thompson,Joshua D. Rabinowitz,Christian M. Metallo,Matthew G. Vander Heiden,Matthew G. Vander Heiden,Dafna Bar-Sagi +14 more
TL;DR: It is shown that Ras-transformed cells use macropinocytosis to transport extracellular protein into the cell, and its pharmacological inhibition compromises the growth of Ras- transformed pancreatic tumour xenografts.
Journal ArticleDOI
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
Jason W. Locasale,Alexandra R. Grassian,Tamar Melman,Costas A. Lyssiotis,Katherine R. Mattaini,Adam J. Bass,Adam J. Bass,Gregory J. Heffron,Christian M. Metallo,Taru A. Muranen,Hadar Sharfi,Atsuo T. Sasaki,Dimitrios Anastasiou,Edouard Mullarky,Natalie I. Vokes,Mika Sasaki,Rameen Beroukhim,Rameen Beroukhim,Gregory Stephanopoulos,Azra H. Ligon,Matthew Meyerson,Matthew Meyerson,Andrea L. Richardson,Lynda Chin,Gerhard Wagner,John M. Asara,Joan S. Brugge,Lewis C. Cantley,Matthew G. Vander Heiden,Matthew G. Vander Heiden +29 more
TL;DR: It is found that in some cancer cells a relatively large amount of glycolytic carbon is diverted into serine and glycine metabolism through phosphoglycerate dehydrogenase (PHGDH).
Journal ArticleDOI
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Dimitrios Anastasiou,Yimin Yu,William J. Israelsen,Jian-kang Jiang,Matthew B. Boxer,Bum Soo Hong,Wolfram Tempel,Svetoslav Dimov,Min Shen,Abhishek K. Jha,Hua Yang,Katherine R. Mattaini,Christian M. Metallo,Brian P. Fiske,Kevin D. Courtney,Scott E. Malstrom,Tahsin M. Khan,Charles Kung,Amanda P. Skoumbourdis,Henrike Veith,Noel Southall,Martin J. Walsh,Kyle R. Brimacombe,William Leister,Sophia Y. Lunt,Zachary R. Johnson,Katharine E. Yen,Kaiko Kunii,Shawn M. Davidson,Heather R. Christofk,Christopher P. Austin,James Inglese,Marian H. Harris,John M. Asara,Gregory Stephanopoulos,Francesco G. Salituro,Shengfang Jin,Lenny Dang,Douglas S. Auld,Hee-Won Park,Lewis C. Cantley,Craig J. Thomas,Matthew G. Vander Heiden,Matthew G. Vander Heiden +43 more
TL;DR: It is shown that expression of PKM1, the pyruvate kinase isoform with high constitutive activity, or exposure to published small molecule PKM2 activators inhibit growth of xenograft tumors and support the notion that small molecule activation ofPKM2 can interfere with anabolic metabolism.