C
Costanza Sagrinati
Researcher at University of Florence
Publications - 21
Citations - 3629
Costanza Sagrinati is an academic researcher from University of Florence. The author has contributed to research in topics: Kidney & Progenitor cell. The author has an hindex of 16, co-authored 21 publications receiving 3350 citations.
Papers
More filters
Journal ArticleDOI
Isolation and Characterization of Multipotent Progenitor Cells from the Bowman’s Capsule of Adult Human Kidneys
Costanza Sagrinati,Giuseppe Stefano Netti,Benedetta Mazzinghi,Elena Lazzeri,Francesco Liotta,Francesca Frosali,Elisa Ronconi,Claudia Meini,Mauro Gacci,Roberta Squecco,Marco Carini,Loreto Gesualdo,Fabio Francini,Enrico Maggi,Francesco Annunziato,Laura Lasagni,Mario Serio,Sergio Romagnani,Paola Romagnani +18 more
TL;DR: This study demonstrates the existence and provides the characterization of a population of resident multipotent progenitor cells in adult human glomeruli, potentially opening new avenues for the development of regenerative medicine in patients who have renal diseases.
Journal ArticleDOI
An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4.
Laura Lasagni,Michela Francalanci,Francesco Annunziato,Elena Lazzeri,Stefano Giannini,Lorenzo Cosmi,Costanza Sagrinati,Benedetta Mazzinghi,Claudio Orlando,Enrico Maggi,Fabio Marra,Sergio Romagnani,Mario Serio,Paola Romagnani +13 more
TL;DR: A distinct, previously unrecognized receptor named CXCR3-B is described, derived from an alternative splicing of the CX CR3 gene that mediates the angiostatic activity of CxCR3 ligands and also acts as functional receptor for CXCL4.
Journal ArticleDOI
Regeneration of Glomerular Podocytes by Human Renal Progenitors
Elisa Ronconi,Costanza Sagrinati,Maria Lucia Angelotti,Elena Lazzeri,Benedetta Mazzinghi,Lara Ballerini,Eliana Parente,Francesca Becherucci,Mauro Gacci,Marco Carini,Enrico Maggi,Mario Serio,Gabriella B. Vannelli,Laura Lasagni,Sergio Romagnani,Paola Romagnani +15 more
TL;DR: It is demonstrated that in the adult human kidney, CD133+CD24+ cells consist of a hierarchical population of progenitors that are arranged in a precise sequence within Bowman's capsule and exhibit heterogeneous potential for differentiation and regeneration.
Journal ArticleDOI
Characterization of Renal Progenitors Committed Toward Tubular Lineage and Their Regenerative Potential in Renal Tubular Injury
Maria Lucia Angelotti,Elisa Ronconi,Lara Ballerini,Anna Julie Peired,Benedetta Mazzinghi,Costanza Sagrinati,Eliana Parente,Mauro Gacci,Marco Carini,Mario Rotondi,Agnes B. Fogo,Elena Lazzeri,Laura Lasagni,Paola Romagnani,Paola Romagnani +14 more
TL;DR: It is demonstrated that CD133+CD24+ renal progenitors can be distinguished in distinct subpopulations from normal human kidneys based on the surface expression of vascular cell adhesion molecule 1, also known as CD106.
Journal ArticleDOI
Essential but differential role for CXCR4 and CXCR7 in the therapeutic homing of human renal progenitor cells
Benedetta Mazzinghi,Elisa Ronconi,Elena Lazzeri,Costanza Sagrinati,Lara Ballerini,Maria Lucia Angelotti,Eliana Parente,Rosa Mancina,Giuseppe Stefano Netti,Francesca Becherucci,Mauro Gacci,Marco Carini,Loreto Gesualdo,Mario Rotondi,Enrico Maggi,Laura Lasagni,Mario Serio,Sergio Romagnani,Paola Romagnani +18 more
TL;DR: It is demonstrated here that among all known chemokine receptors, human renal progenitor cells exhibit high expression of both stromal-derived factor-1 (SDF-1) receptors, CXCR4 and CX CR7, which suggest that CXcr4 andCXCR7 play an essential, but differential, role in the therapeutic homing of human kidneys showing regenerative potential for injured renal tissue of SCID mice.