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Craig A. Simmons
Researcher at University of Toronto
Publications - 229
Citations - 11779
Craig A. Simmons is an academic researcher from University of Toronto. The author has contributed to research in topics: Aortic valve & Medicine. The author has an hindex of 56, co-authored 202 publications receiving 10438 citations. Previous affiliations of Craig A. Simmons include University of Michigan & Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update.
Nalini M. Rajamannan,Frank Evans,Elena Aikawa,K. Jane Grande-Allen,Linda L. Demer,Donald D. Heistad,Craig A. Simmons,Kristyn S. Masters,Patrick Mathieu,Kevin D. O'Brien,Frederick J. Schoen,Dwight A. Towler,Ajit P. Yoganathan,Catherine M Otto +13 more
TL;DR: Calcific aortic valve disease (CAVD) encompasses the range of disease from initial alterations in the cell biology of the leaflets to end-stage calcification resulting in left ventricular outflow obstruction as mentioned in this paper.
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Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells
TL;DR: Test data demonstrate that appropriate combinations of soluble and biomaterial-mediated regulatory signals in cell-based tissue engineering systems can result in both more efficient and more effective tissue regeneration.
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Influence of substrate stiffness on the phenotype of heart cells
Bashir Bhana,Rohin K. Iyer,Wen Li Kelly Chen,Ruogang Zhao,Krista L. Sider,Morakot Likhitpanichkul,Craig A. Simmons,Milica Radisic +7 more
TL;DR: In this paper, the influence of substrate mechanical stiffness on the heart cell phenotype and functional properties was investigated using 3, 22, 50, and 144-kPa polyacrylamide (PA) gel stiffness.
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Calcification by Valve Interstitial Cells Is Regulated by the Stiffness of the Extracellular Matrix
TL;DR: Differentiation of VICs to pathological phenotypes in response to biochemical cues is modulated by matrix stiffness, and although osteogenic or myofibrogenic differentiation of Vics can result in calcification, the processes are distinct.
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Boning up on Wolff's Law: mechanical regulation of the cells that make and maintain bone.
TL;DR: Dissection of the role of mechanics in regulating bone cell fate and function, and translation of that knowledge to improved therapies, requires identification of relevant cues, multifactorial experimental approaches, and advanced model systems that mimic the mechanobiological environment.