Craig R. Braun

TL;DR: A competitive and partially redundant relationship between transaminases and GLUD is described, and they reveal how coupling of glutamate-derived carbon and nitrogen metabolism can be regulated to support cell proliferation.

TL;DR: Production of full-length, monomeric BAK by mutagenesis-based solubilization of its C-terminal α-helical surface is reported, providing opportunities for developing proapoptotic agents that activate the death pathway through direct but differential engagement of BAK and BAX.

TL;DR: Data reveal a previously unappreciated binding site for targeted inhibition of BAX and suggest that the BCL-2 BH4 domain may participate in apoptosis blockade by a noncanonical interaction mechanism.

TL;DR: A two-dimensional multiplexing workflow is presented that utilizes synthetic peptides for each protein to prompt the simultaneous quantification of >100 peptides from up to ten mixed sample conditions and elucidated a correlation between the expression of key proteins and their cellular response to drug treatment.

TL;DR: It is demonstrated that Red1 partners with other proteins to silence meiotic gene expression at the post-transcriptional level and Conservation of a NURS-like complex in human cells suggests that this pathway plays an ancient and fundamental role in RNA silencing.