J
Jonathan L. Coloff
Researcher at Harvard University
Publications - 40
Citations - 4198
Jonathan L. Coloff is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer cell & Programmed cell death. The author has an hindex of 24, co-authored 37 publications receiving 3524 citations. Previous affiliations of Jonathan L. Coloff include Iowa State University & Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
Haoqiang Ying,Alec C. Kimmelman,Costas A. Lyssiotis,Sujun Hua,Gerald C. Chu,Eliot Fletcher-Sananikone,Jason W. Locasale,Jaekyoung Son,Hailei Zhang,Jonathan L. Coloff,Haiyan Yan,Wei Wang,Shujuan Chen,Andrea Viale,Hongwu Zheng,Jihye Paik,Carol Lim,Alexander R. Guimaraes,Eric S. Martin,Jeffery Chang,Aram F. Hezel,Samuel R. Perry,Jian Hu,Boyi Gan,Yonghong Xiao,John M. Asara,Ralph Weissleder,Y. Alan Wang,Lynda Chin,Lewis C. Cantley,Ronald A. DePinho +30 more
TL;DR: In vivo mechanistic insights are provided into how oncogenic Kras promotes metabolic reprogramming in native tumors and illuminates potential metabolic targets that can be exploited for therapeutic benefit in PDAC.
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Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival
Nancie J. MacIver,Sarah R. Jacobs,Heather L. Wieman,Jessica A. Wofford,Jonathan L. Coloff,Jeffrey C. Rathmell +5 more
TL;DR: Understanding of the signals that regulate the expression and localization of glucose transporter 1 (Glut1) to allow glucose uptake in T cells are beginning to be understood and may lead to therapeutic strategies to target some forms of cancer or autoimmunity.
Journal ArticleDOI
Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells.
Jonathan L. Coloff,J. Patrick Murphy,Craig R. Braun,Isaac S. Harris,Laura M. Shelton,Kenjiro Kami,Steven P. Gygi,Laura M. Selfors,Joan S. Brugge +8 more
TL;DR: A competitive and partially redundant relationship between transaminases and GLUD is described, and they reveal how coupling of glutamate-derived carbon and nitrogen metabolism can be regulated to support cell proliferation.
Journal ArticleDOI
Glycogen Synthase Kinase 3α and 3β Mediate a Glucose-Sensitive Antiapoptotic Signaling Pathway To Stabilize Mcl-1
Yuxing Zhao,Brian J. Altman,Jonathan L. Coloff,Catherine E. Herman,Sarah R. Jacobs,Heather L. Wieman,Jessica A. Wofford,Leah N. DiMascio,Olga Ilkayeva,Ameeta Kelekar,Tannishtha Reya,Jeffrey C. Rathmell +11 more
TL;DR: A novel nutrient-sensitive mechanism linking glucose metabolism and Bcl-2 family proteins via GSK-3 that may promote survival of cells with high rates of glucose utilization, such as growth factor-stimulated or cancerous cells is provided.
Journal ArticleDOI
Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation
Alexandra R. Grassian,Christian M. Metallo,Jonathan L. Coloff,Gregory Stephanopoulos,Joan S. Brugge +4 more
TL;DR: A novel mechanism by which ECM attachment, growth factors, and oncogenes modulate the metabolic fate of glucose by controlling PDK4 expression and PDH flux to influence proliferation is identified.