C
Cristina Bottino
Researcher at University of Genoa
Publications - 186
Citations - 24702
Cristina Bottino is an academic researcher from University of Genoa. The author has contributed to research in topics: Receptor & Interleukin 21. The author has an hindex of 72, co-authored 179 publications receiving 23379 citations. Previous affiliations of Cristina Bottino include University of Geneva & Ludwig Institute for Cancer Research.
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Journal ArticleDOI
Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis.
Alessandro Moretta,Cristina Bottino,Massimo Vitale,Daniela Pende,Claudia Cantoni,Maria Cristina Mingari,Roberto Biassoni,Lorenzo Moretta +7 more
TL;DR: The discovery of MHC-specific inhibitory receptors in mouse and in human clarified the molecular basis of this important NK cell function, and some of these receptors have now been identified in humans, thus shedding some light on the molecular mechanisms involved in NK cell activation during the process of natural cytotoxicity.
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Receptors for hla class-i molecules in human natural killer cells
Alessandro Moretta,Cristina Bottino,Massimo Vitale,Daniela Pende,Roberto Biassoni,Maria Cristina Mingari,Lorenzo Moretta +6 more
TL;DR: These receptors exert an inhibiting activity on T cell receptor- mediated functions and offer a valuable model to analyze the regulatory mechanisms involved in receptor-mediated cell activation and inactivation.
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Identification of PVR (CD155) and Nectin-2 (CD112) as Cell Surface Ligands for the Human DNAM-1 (CD226) Activating Molecule
Cristina Bottino,Roberta Castriconi,Daniela Pende,Paola Rivera,Marina Nanni,Marina Nanni,Barbara Carnemolla,Claudia Cantoni,Claudia Cantoni,Jessica Grassi,Stefania Marcenaro,Nicolas Reymond,Massimo Vitale,Lorenzo Moretta,Lorenzo Moretta,Marc Lopez,Alessandro Moretta +16 more
TL;DR: The surface expression of PVR or Nectin-2 in cell transfectants resulted in DNAM-1–dependent enhancement of NK-mediated lysis of these target cells, and this lysis was inhibited or even virtually abrogated upon mAb-mediated masking of DNam-1 (on NK cells) or PVR and NectIn-2 ligands (on celltransfectants).
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Identification and Molecular Characterization of Nkp30, a Novel Triggering Receptor Involved in Natural Cytotoxicity Mediated by Human Natural Killer Cells
Daniela Pende,Silvia Parolini,A. Pessino,Simona Sivori,Raffaella Augugliaro,Luigia Morelli,Emanuela Marcenaro,Laura Accame,Angela Malaspina,Roberto Biassoni,Cristina Bottino,Lorenzo Moretta,Alessandro Moretta +12 more
TL;DR: NKp30 is identified, a novel 30-kD triggering receptor selectively expressed by all resting and activated human natural killer (NK) cells, and is associated with CD3ζ chains that become tyrosine phosphorylated upon sodium pervanadate treatment of NK cells.
Journal ArticleDOI
NKp44, a Novel Triggering Surface Molecule Specifically Expressed by Activated Natural Killer Cells, Is Involved in Non–Major Histocompatibility Complex–restricted Tumor Cell Lysis
Massimo Vitale,Cristina Bottino,Simona Sivori,Lorenza Sanseverino,Roberta Castriconi,Emanuela Marcenaro,Raffaella Augugliaro,Lorenzo Moretta,Alessandro Moretta +8 more
TL;DR: It is shown that p46 and NKp44 are coupled to the intracytoplasmic transduction machinery via the association with CD3ζ or KARAP/DAP12, respectively; these associated molecules are tyrosine phosphorylated upon NK cell stimulation.