L
Luigia Morelli
Researcher at University of Genoa
Publications - 18
Citations - 3915
Luigia Morelli is an academic researcher from University of Genoa. The author has contributed to research in topics: Receptor & Natural killer cell. The author has an hindex of 15, co-authored 18 publications receiving 3793 citations. Previous affiliations of Luigia Morelli include University of Brescia.
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Journal ArticleDOI
Identification and Molecular Characterization of Nkp30, a Novel Triggering Receptor Involved in Natural Cytotoxicity Mediated by Human Natural Killer Cells
Daniela Pende,Silvia Parolini,A. Pessino,Simona Sivori,Raffaella Augugliaro,Luigia Morelli,Emanuela Marcenaro,Laura Accame,Angela Malaspina,Roberto Biassoni,Cristina Bottino,Lorenzo Moretta,Alessandro Moretta +12 more
TL;DR: NKp30 is identified, a novel 30-kD triggering receptor selectively expressed by all resting and activated human natural killer (NK) cells, and is associated with CD3ζ chains that become tyrosine phosphorylated upon sodium pervanadate treatment of NK cells.
Journal ArticleDOI
Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity.
A. Pessino,Simona Sivori,Cristina Bottino,Angela Malaspina,Luigia Morelli,Lorenzo Moretta,Roberto Biassoni,Alessandro Moretta +7 more
TL;DR: The first characterization of the molecular structure of a NK-specific receptor involved in the mechanism of NK cell activation during natural cytotoxicity is reported, involving a novel member of the immunoglobulin (Ig) superfamily.
Journal ArticleDOI
P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities.
Alessandro Moretta,Massimo Vitale,Cristina Bottino,Anna Maria Orengo,Luigia Morelli,Raffaella Augugliaro,M Barbaresi,Ermanno Ciccone,Lorenzo Moretta +8 more
TL;DR: Support to the concept that p58 molecules represent a NK receptor delivering a negative signal was provided by experiments in which the entire anti-p58 mAbs could inhibit the lysis of unprotected Fc gamma R- target cells, thus mimicking the inhibitory effect of MHC class I molecules.
Journal ArticleDOI
p46, a Novel Natural Killer Cell–specific Surface Molecule That Mediates Cell Activation
Simona Sivori,Massimo Vitale,Luigia Morelli,Lorenza Sanseverino,Raffaella Augugliaro,Cristina Bottino,Lorenzo Moretta,Alessandro Moretta +7 more
TL;DR: Both the unique cellular distribution and functional capability of p46 molecules suggest a possible role in the mechanisms of non-major histocompatibility complex–restricted cytolysis mediated by human NK cells.
Journal ArticleDOI
Existence of both inhibitory (p58) and activatory (p50) receptors for HLA-C molecules in human natural killer cells.
Alessandro Moretta,Simona Sivori,Massimo Vitale,Daniela Pende,Luigia Morelli,Raffaella Augugliaro,Cristina Bottino,Lorenzo Moretta +7 more
TL;DR: It is shown that EB6 molecules may also act as receptors mediating NK cell triggering, and clones expressing the activatory p50/EB6 molecules consistently coexpressed inhibitory receptors for other HLA class I alleles.