A
Alessandro Moretta
Researcher at University of Genoa
Publications - 415
Citations - 54076
Alessandro Moretta is an academic researcher from University of Genoa. The author has contributed to research in topics: Interleukin 21 & Receptor. The author has an hindex of 123, co-authored 415 publications receiving 50509 citations. Previous affiliations of Alessandro Moretta include Hebrew University of Jerusalem & Boston Children's Hospital.
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Journal ArticleDOI
Innate or Adaptive Immunity? The Example of Natural Killer Cells
Eric Vivier,David H. Raulet,Alessandro Moretta,Michael A. Caligiuri,Laurence Zitvogel,Lewis L. Lanier,Wayne M. Yokoyama,Sophie Ugolini,Sophie Ugolini +8 more
TL;DR: NK cells are now recognized to express a repertoire of activating and inhibitory receptors that is calibrated to ensure self-tolerance while allowing efficacy against assaults such as viral infection and tumor development.
Journal ArticleDOI
Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis.
Alessandro Moretta,Cristina Bottino,Massimo Vitale,Daniela Pende,Claudia Cantoni,Maria Cristina Mingari,Roberto Biassoni,Lorenzo Moretta +7 more
TL;DR: The discovery of MHC-specific inhibitory receptors in mouse and in human clarified the molecular basis of this important NK cell function, and some of these receptors have now been identified in humans, thus shedding some light on the molecular mechanisms involved in NK cell activation during the process of natural cytotoxicity.
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Receptors for hla class-i molecules in human natural killer cells
Alessandro Moretta,Cristina Bottino,Massimo Vitale,Daniela Pende,Roberto Biassoni,Maria Cristina Mingari,Lorenzo Moretta +6 more
TL;DR: These receptors exert an inhibiting activity on T cell receptor- mediated functions and offer a valuable model to analyze the regulatory mechanisms involved in receptor-mediated cell activation and inactivation.
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Identification of PVR (CD155) and Nectin-2 (CD112) as Cell Surface Ligands for the Human DNAM-1 (CD226) Activating Molecule
Cristina Bottino,Roberta Castriconi,Daniela Pende,Paola Rivera,Marina Nanni,Marina Nanni,Barbara Carnemolla,Claudia Cantoni,Claudia Cantoni,Jessica Grassi,Stefania Marcenaro,Nicolas Reymond,Massimo Vitale,Lorenzo Moretta,Lorenzo Moretta,Marc Lopez,Alessandro Moretta +16 more
TL;DR: The surface expression of PVR or Nectin-2 in cell transfectants resulted in DNAM-1–dependent enhancement of NK-mediated lysis of these target cells, and this lysis was inhibited or even virtually abrogated upon mAb-mediated masking of DNam-1 (on NK cells) or PVR and NectIn-2 ligands (on celltransfectants).
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Identification and Molecular Characterization of Nkp30, a Novel Triggering Receptor Involved in Natural Cytotoxicity Mediated by Human Natural Killer Cells
Daniela Pende,Silvia Parolini,A. Pessino,Simona Sivori,Raffaella Augugliaro,Luigia Morelli,Emanuela Marcenaro,Laura Accame,Angela Malaspina,Roberto Biassoni,Cristina Bottino,Lorenzo Moretta,Alessandro Moretta +12 more
TL;DR: NKp30 is identified, a novel 30-kD triggering receptor selectively expressed by all resting and activated human natural killer (NK) cells, and is associated with CD3ζ chains that become tyrosine phosphorylated upon sodium pervanadate treatment of NK cells.