C
Cristina C. Rohena
Researcher at University of California, San Diego
Publications - 23
Citations - 491
Cristina C. Rohena is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Microtubule & Tubulin. The author has an hindex of 10, co-authored 23 publications receiving 408 citations. Previous affiliations of Cristina C. Rohena include University of Texas at San Antonio & University of Texas Health Science Center at San Antonio.
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Journal ArticleDOI
Drosophila Ringmaker regulates microtubule stabilization and axonal extension during embryonic development
Rosa E. Mino,Stephen L. Rogers,April L. Risinger,Cristina C. Rohena,Cristina C. Rohena,Swati Banerjee,Manzoor A. Bhat +6 more
TL;DR: The characterization of Drosophila Ringmaker (Ringer) is reported, and it is demonstrated that Ringer regulates axonal growth by affecting microtubular organization during CNS development.
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GIV•Kindlin Interaction Is Required for Kindlin-Mediated Integrin Recognition and Activation.
Cristina C. Rohena,Nicholas A. Kalogriopoulos,Navin Rajapakse,Suchismita Roy,Inmaculada Lopez-Sanchez,Jailal N. G. Ablack,Debashis Sahoo,Pradipta Ghosh +7 more
TL;DR: How the GIV•Kindlin-2 complex has a 2-fold impact is elucidate: it allosterically synergizes integrin activation and enables β1-integrins to indirectly access and modulate trimeric GTPases via the complex.
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Biochemical, Biophysical and Cellular Techniques to Study the Guanine Nucleotide Exchange Factor, GIV/Girdin.
Pradipta Ghosh,Nicolas Aznar,Lee Swanson,I-Chung Lo,Inmaculada Lopez-Sanchez,Jason Ear,Cristina C. Rohena,Nicholas A. Kalogriopoulos,Linda P. Joosen,Ying Dunkel,Nina N. Sun,Peter Nguyen,Deepali Bhandari +12 more
TL;DR: This work provides the most up‐to‐date overview of protocols that have generated most of what the authors know today about noncanonical G protein activation by GIV and its relevance in health and disease.
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Biological Characterization of an Improved Pyrrole-Based Colchicine Site Agent Identified through Structure-Based Design.
Cristina C. Rohena,Nakul Telang,Chenxiao Da,April L. Risinger,James A. Sikorski,Glen E. Kellogg,John T. Gupton,Susan L. Mooberry +7 more
TL;DR: A refined model of the colchicine site on tubulin was used to design an improved analog of the pyrrole parent compound, JG-03-14, and the optimized compound, NT-7-16, was evaluated in biological assays that confirm that it has potent activities as a new colchichine site microtubule depolymerizer.
Journal ArticleDOI
Janus Compounds, 5-Chloro-N4-methyl-N4-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, Cause Both Microtubule Depolymerizing and Stabilizing Effects
Cristina C. Rohena,April L. Risinger,Ravi Kumar Vyas Devambatla,Nicholas F. Dybdal-Hargreaves,Roma Kaul,Shruti Choudhary,Aleem Gangjee,Susan L. Mooberry +7 more
TL;DR: The identification of synthetically tractable, small molecules that elicit microtubule stabilizing effects is a significant finding with the potential to identify new mechanisms of microtubules stabilization.