Showing papers in "iScience in 2020"

TL;DR: In the last two decades, fluoro-chemicals have been associated with significant advances in the agrochemical development process and this analysis reveals the unique relationship between fluorine and agrochemicals.

TL;DR: This work investigates the potential role of this novel S1/S2 cleavage site and presents direct biochemical evidence for proteolytic processing by a variety of proteases in the context of the origin of SARS-CoV-2, viral stability and transmission.

TL;DR: Bioinformatics approaches combining human-virus protein interaction prediction and protein docking based on crystal structures have revealed the high affinity between human dipeptidyl peptidase 4 (DPP4) and the spike (S) receptor-binding domain of SARS-CoV-2.

TL;DR: The optical requirements in near-eye displays poised by the human visual system are analyzed and compared against the specifications of state-of-the-art devices and potential solutions to address these challenges are presented case by case.

TL;DR: The results highlight the potentials of defect engineering as a strategy of improving the electrochemical performance of β-MnO2 in aqueous rechargeable batteries.

TL;DR: Data indicate that a robust sIgA-dominant SARS-CoV-2 Ab response in human milk after infection should be expected in a significant majority of individuals, and further research is highly warranted to determine Ab functionality, and the potential for exploiting extracted milk sIGA for therapeutic use.

TL;DR: The present results show that scCATCH accurately revealed cell identities with high reproducibility, thus potentially providing insights into mechanisms underlying disease pathogenesis and progression.

TL;DR: The SARS-CoV-2 Nsp9 structure revealed the high level of structural conservation within the NSP9 family and the exogenous peptide binding site is close to the dimer interface and impacted the relative juxtapositioning of the monomers within the homodimer.

TL;DR: It is speculated that the presence of a redundant furin cut site in its Spike protein is responsible for SARS-CoV-2’s stronger infectious than other coronaviruses, which leads to higher membrane fusion efficiency.

TL;DR: This review focuses on a broad description of currently available diagnostic tests to detect either the virus (SARS-CoV-2) or virus-induced immune responses and lays out the shortcomings of certain tests and future needs.

TL;DR: Sustentacular cells, which maintain the integrity of olfactory sensory neurons, express ACE2 and TMPRSS2, and represent a potential entry door for SARS-CoV-2 in a neuronal sensory system that is in direct connection with the brain.

TL;DR: The results are consistent with a model in which SARS-CoV-2 infection induces liver damage associated with dyslipidemia and oxidative stress, and PCA analyses discriminating both cohorts highlighted the impact that the infection has in overall metabolism.

TL;DR: The digital coding representations of metamaterials make it possible to bridge the digital world and physical world using the meetamaterial platform and make the metamMaterials process digital information directly, resulting in information metammaterials.

TL;DR: Single-cell RNA-sequencing is used to uncover gene expression signatures of over 53,000 individual cells during skeletal muscle regeneration and provide insights into the cellular and molecular underpinning of skeletal muscle Regeneration.

TL;DR: This study provides a green and cost-efficient strategy for the control of microplastics contamination in the environment by investigating the photocatalytic degradation of typical microplastic such as polystyrene (PS) microspheres and polyethylene (PE) over TiO2 nanoparticle films under UV light irradiation.

TL;DR: The current state of the art about the diagnosis and prognosis of short circuit is reviewed, covering the method and the key indicators and the findings provide important insights regarding how to improve the battery safety.

TL;DR: The ferroptosis potential index (FPI) was established to reveal the functional roles of ferroPTosis and noticed that the FPI was higher in tumors than in normal tissues in most cancers and was associated with subtypes and clinical features.

TL;DR: A convolution neural network model is developed to detect and classify CAs, using a large 12-lead ECG dataset provided by the China Physiological Signal Challenge (CPSC) 2018, and shows that concurrent CAs were adequately predictive for 476 patients with multiple types of CA diagnoses in the dataset.

TL;DR: A historic view is taken to summarize a few main interdisciplinary areas of research on nucleic acid enzymes that may have broader impacts on the search for new DNAzymes and ribozymes.

TL;DR: A Co-doped nanorod-like RuO2 electrocatalyst with an abundance of oxygen vacancies achieved through the facile, one-step annealing of a Ru-exchanged ZIF-67 derivative exhibits ultra-high OER performance in acidic media.

TL;DR: Current progress in engineering yeast cell factories for production of natural products, including terpenoids, alkaloids, and phenylpropanoids is summarized and advanced strategies in metabolic engineering at three different dimensions are discussed.

TL;DR: A method MutaBind2 is developed, which estimates the impacts of single as well as multiple mutations on protein-protein interactions and shows a distinct improvement especially in evaluating the effects of mutations increasing binding affinity.

TL;DR: The microbiology of DIET is reviewed, molecular strategies for monitoring DIET in anaerobic digesters are suggested, and approaches for re-engineering digester design and practices to encourage DIET are proposed.

TL;DR: This review surveys the understanding of the structural biology of the cannabinoids and their target receptors including both a critical comparison of the extant crystal structures and the computationally derived homology models, as well as an in-depth discussion about the binding modes of the major cannabinoids.

TL;DR: Recent developments in dry, bi-, and tri-reforming, where the CO2 in biogas is used as an oxidant/partial oxidant, are reviewed.

TL;DR: This review introduced the research progress on the typical VUV photodetectors based on scintillator, photomultiplier tube, semiconductor, and gas, with their unique advantages and optimal performance indicators in different applications, and pointed out the remaining challenges.

TL;DR: A combined experimental and theoretical investigation into electrocatalytic CO2RR on Ti- and Mo-based MXene catalysts reveals the critical role of the Tx group: a smaller overpotential is found to occur at lower amounts of –F termination.

TL;DR: This review will serve to appreciate why titanium and its alloys are frequently used orthopedic biomaterials and address some of the challenges facing these biommaterials currently, including the significant problem of device-associated infection.

TL;DR: The described intestinal clock represents a unique quantitative model of gut microflora aging and provides a starting point for building host aging and gut community succession into a single narrative.

TL;DR: The applications of nanotechnology are wide ranging, and developing functional nanomaterials for agri-food applications from nature-derived polymers is widely conceived as a sustainable approach that is safer for human and animal consumption.