Cristina Lazzeri

TL;DR: It is demonstrated that transcriptional activation of the TCL1 protooncogene can cause malignant transformation of T lymphocytes, indicating the role of TCL2 in the initiation of malignant transformed T cell neoplasia in T prolymphocytic leukemias and T chronic lymphocyticLeukmias.

TL;DR: This work profiled the expression of 470 microRNAs in a cohort of 22 SS patients, and it identified 45 miRNAs differentially expressed between SS and controls, and defined a signature of 14 mi RNAs, potentially able to discriminate patients with unfavorable and favorable outcome.

TL;DR: Analysis of data from a large tumor lymphoma data bank including 194 cases of lymphoproliferative disorders of B- and T-cell origin as well as reactive lymphoid tissues indicates that TCL1 is expressed in more differentiated B cells, under both reactive and neoplastic conditions, from antigen committed B cells and in germinal center B cell cells and is down-regulated in the latest stage ofB-cell differentiation.

TL;DR: It is reported that TCL1, located at the 14q32.1 region, is also overexpressed in 10 of 10 ATL specimens, indicating that this gene may play an important role in the pathogenesis of this disease.

TL;DR: Functional CXCL13 homeostatic chemokine is strongly up-regulated in SS cells, well-detectable in skin lesions and lymph nodes, and measurable at high concentration in plasma of SS patients, at different levels during disease progression.