Maria Grazia Narducci

TL;DR: The TCL1 gene sequence, which, to the authors' knowledge, shows no sequence homology with other human genes, is preferentially expressed early in T- and B-lymphocyte differentiation.

TL;DR: It is demonstrated that transcriptional activation of the TCL1 protooncogene can cause malignant transformation of T lymphocytes, indicating the role of TCL2 in the initiation of malignant transformed T cell neoplasia in T prolymphocytic leukemias and T chronic lymphocyticLeukmias.

TL;DR: It is reported that SS cells express a functionally active CXCR4 and that its ligand SDF-1 is abundantly produced in the skin, which represents the main destination of SS cell spreading and could play an important role in skin homing of SS through the regulatory activity of CD26.

TL;DR: This work profiled the expression of 470 microRNAs in a cohort of 22 SS patients, and it identified 45 miRNAs differentially expressed between SS and controls, and defined a signature of 14 mi RNAs, potentially able to discriminate patients with unfavorable and favorable outcome.

TL;DR: Analysis of data from a large tumor lymphoma data bank including 194 cases of lymphoproliferative disorders of B- and T-cell origin as well as reactive lymphoid tissues indicates that TCL1 is expressed in more differentiated B cells, under both reactive and neoplastic conditions, from antigen committed B cells and in germinal center B cell cells and is down-regulated in the latest stage ofB-cell differentiation.