Roberta Bichi

TL;DR: Detailed deletion and expression analysis shows that miR15 and miR16 are located within a 30-kb region of loss in CLL, and that both genes are deleted or down-regulated in the majority (≈68%) of CLL cases.

TL;DR: The loss of heterozygosity observed at chromosome 6q25–q26 may contribute to the initiation and/or progression of cancer by inactivating or reducing the expression of the Parkin gene, another example of a large tumor suppressor gene, like FHIT and WWOX, located at a common fragile site.

TL;DR: It is shown that Akt interacts with Nur77 and inactivates Nur77 by phosphorylated Ser-350 of the Nur77 protein within its DNA-binding domain in a phosphatidylinositol 3-kinase-dependent manner, connecting the phosph atidyl inositol3-kinases-dependent Akt pathway and a nuclear receptor pathway.

TL;DR: It is demonstrated that transcriptional activation of the TCL1 protooncogene can cause malignant transformation of T lymphocytes, indicating the role of TCL2 in the initiation of malignant transformed T cell neoplasia in T prolymphocytic leukemias and T chronic lymphocyticLeukmias.

TL;DR: The cloning, mapping, and expression analysis of the human and murine TCL1/Tcl1 locus suggest a similar or complementary function of these proteins in early embryogenesis.