Cristina Padula

TL;DR: In this paper, a review of different characterization techniques for polymeric micelles is presented, from the ones used for the determination of micells basic characteristics (critical micellar concentration, size, surface charge, morphology) to the more complex approaches used to figure out micellers kinetic stability, drug release and behavior in the presence of biological substrates (fluids, cells and tissues).

TL;DR: It can be concluded that the monolayer film acts as a water-permeable transdermal/dermal patch on application to the skin, and the permeation kinetics across the skin was not linear, but the patch acted as a matrix controlling drug delivery.

TL;DR: Developing an aqueous micellar formulation for an efficient cyclosporine delivery to the ocular tissues, using a water-soluble derivative of vitamin E and vitamin E succinate from TPGS and poloxamer 407 as excipients demonstrated the capability of mixed micelles to diffuse into the sclera and sustain cyclospora delivery.

TL;DR: The results obtained with CPPs for the treatment of anterior and posterior segment eye diseases will be introduced, with a focus on non-invasive or minimally invasive administration, shifting from C PPs capability to obtain intracellular delivery to their ability to cross biological barriers.

TL;DR: From the data obtained it can be concluded that the transdermal film acts as a matrix controlling drug delivery, and the choice of the adhesive seems to be the most important variable governing drug transport.