Sara Nicoli

TL;DR: In this paper, a review of different characterization techniques for polymeric micelles is presented, from the ones used for the determination of micells basic characteristics (critical micellar concentration, size, surface charge, morphology) to the more complex approaches used to figure out micellers kinetic stability, drug release and behavior in the presence of biological substrates (fluids, cells and tissues).

TL;DR: In this review, nanomedicine delivery based on particle engineering exploiting surface electrostatic charges, mucoadhesive polymers, or chemical moieties targeting the nasal epithelium will be discussed and critically evaluated in relation to nose-to-brain delivery.

TL;DR: It can be concluded that the monolayer film acts as a water-permeable transdermal/dermal patch on application to the skin, and the permeation kinetics across the skin was not linear, but the patch acted as a matrix controlling drug delivery.

TL;DR: Porcine sclera can be considered a good model for human sClera for in vitro permeation experiments of both low and high molecular weight compounds, and if the different tissue thickness is taken into account, comparable permeability was demonstrated.

TL;DR: Developing an aqueous micellar formulation for an efficient cyclosporine delivery to the ocular tissues, using a water-soluble derivative of vitamin E and vitamin E succinate from TPGS and poloxamer 407 as excipients demonstrated the capability of mixed micelles to diffuse into the sclera and sustain cyclospora delivery.