J
Justin J. Wilson
Researcher at Cornell University
Publications - 122
Citations - 4479
Justin J. Wilson is an academic researcher from Cornell University. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 29, co-authored 98 publications receiving 3160 citations. Previous affiliations of Justin J. Wilson include State University of New York at Geneseo & Florida State University College of Arts and Sciences.
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Journal ArticleDOI
Synthetic Methods for the Preparation of Platinum Anticancer Complexes
TL;DR: The demonstration in the 1960's that cis-diamminedichloroplatinum(II), or cisplatin, inhibits cellular division of Escherichia coli1 led to the subsequent discovery that this simple coordination compound is also an effective antitumor agent in mouse models.
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Phenanthriplatin, a monofunctional DNA-binding platinum anticancer drug candidate with unusual potency and cellular activity profile
TL;DR: Phenanthriplatin inhibits transcription in live mammalian cells as effectively as cisplatin, despite its inability to form DNA cross-links, and suggests that it may avoid cytoplasmic platinum scavengers with sulfur-donor ligands that convey drug resistance.
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Metal complexes as a promising source for new antibiotics.
Angelo Frei,Johannes Zuegg,Alysha G. Elliott,Murray V. Baker,Stefan Braese,Christopher L. Brown,Feng Chen,Christopher G. Dowson,Gilles Dujardin,Nicole Jung,A. Paden King,Ahmed M. Mansour,Massimiliano Massi,John Moat,Heba A. Mohamed,Anna K. Renfrew,Peter J. Rutledge,Peter J. Sadler,Matthew H. Todd,Matthew H. Todd,Charlotte E. Willans,Justin J. Wilson,Mark E. Cooper,Mark A. T. Blaskovich +23 more
TL;DR: Metal complexes were evaluated against dangerous ESKAPE pathogens and found to have a higher hit-rate than organic molecules.
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Anticancer activity of complexes of the third row transition metals, rhenium, osmium, and iridium
TL;DR: Significant developments within the last six years on the application of rhenium, osmium, and iridium complexes as anticancer drug candidates are summarized.
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Monofunctional and Higher-Valent Platinum Anticancer Agents
TL;DR: In this paper, the authors describe recent developments from their laboratory involving monofunctional platinum(II) complexes together with a historical account of the manner by which they came to investigate these compounds and their relationship to previous studies.