Crocifissa Lo Cunsolo

TL;DR: It is reported that the combined expression of adenovirus E1A, Ha-RasV12, and MDM2 is sufficient to convert a normal human cell into a cancer cell and provides evidence that activation of telomere maintenance strategies is not an obligate characteristic of tumorigenic human cells.

TL;DR: The first complete cytogenetic and molecular characterization of a t(6;11)‐positive RCC of an adult patient, a 54‐year‐old woman, is reported, contributing to define better this rare RCC type, which is typical not only of childhood but can also be found in adulthood.

TL;DR: Through a combined approach integrating RNA-Seq, SNP-array, FISH and PCR techniques, two novel t(15;21) translocations leading to the inactivation of RUNX1 and its partners SIN3A and TCF12 are identified.

TL;DR: An apparent role of FOXP1 and TP63, up to now poorly documented, in the progression of MDS is document in a 79-year woman who is lacking mutations in the TP53 tumor suppressor gene normally associated with poor outcome in myelodysplastic syndrome with 5q-.

TL;DR: Single nucleotide polymorphism (SNP) array analysis of the patient’s PB DNA, accomplished on a CytoScan HD Array according to manufacturer protocols using the ChAS Software, confirmed a deletion that included MIR15A/MIR16-1 and DLEU7 on the der(13) and disclosed a deletion on the derivative chromosome 8.