Attilio Guarini

TL;DR: In patients aged 75 years and younger with primary CNS lymphoma, the addition of high-dose cytarabine to high- dose methotrexate provides improved outcome with acceptable toxicity compared with high- doses of metotrexate alone.

TL;DR: This study adds to the evidence that patients with haematological malignancies have worse outcomes and the general Italian population with COVID-19 has high mortality, by calculating standardised mortality ratios between observed death in the study cohort and expected death by applying stratum-specific mortality rates.

TL;DR: It is reported that pharmacologic inhibition of GS skews M2-polarized macrophages toward the M1-like phenotype, characterized by reduced intracellular glutamine and increased succinate with enhanced glucose flux through glycolysis, which could be partly related to HIF1α activation.

TL;DR: It is concluded that in NHL patients, poor mobilization status is predictive of survival and refractory disease status and chemotherapeutic load before mobilization played a negative role and were associated with poor mobilization.

TL;DR: The distinct endothelial cell gene expression profiles and vascular phenotypes detected in this study may influence remodeling of the bone marrow microenvironment in patients with active multiple myeloma.