M
Michelina Coco
Researcher at Casa Sollievo della Sofferenza
Publications - 20
Citations - 650
Michelina Coco is an academic researcher from Casa Sollievo della Sofferenza. The author has contributed to research in topics: DNA methylation & Methylation. The author has an hindex of 12, co-authored 19 publications receiving 561 citations.
Papers
More filters
Journal ArticleDOI
Frequent epigenetics inactivation of KEAP1 gene in non-small cell lung cancer
Lucia Anna Muscarella,Paola Parrella,Vito D'Alessandro,Annamaria la Torre,Raffaela Barbano,Andrea Fontana,Antonio Tancredi,Vito Guarnieri,Teresa Balsamo,Michelina Coco,Massimiliano Copetti,Fabio Pellegrini,Patrizia De Bonis,Michele Bisceglia,Gerardo Scaramuzzi,Evaristo Maiello,Vanna Maria Valori,Giuseppe Merla,Gianluigi Vendemiale,Vito Michele Fazio +19 more
TL;DR: The results suggest that deregulation of the NRF2/KEAP1 system could play a pivotal role in the cancerogenesis of NSCLC and identifying patients with KEAP1 genetic and epigenetic abnormalities may contribute to disease progression prediction and response to therapy in lung cancer patients.
Journal ArticleDOI
Regulation of KEAP1 expression by promoter methylation in malignant gliomas and association with patient's outcome.
Lucia Anna Muscarella,Raffaela Barbano,Vincenzo D'Angelo,Massimiliano Copetti,Michelina Coco,Teresa Balsamo,Annamaria la Torre,Angelo Notarangelo,Michele Troiano,Salvatore Parisi,Nadia Icolaro,Domenico Catapano,Vanna Maria Valori,Fabio Pellegrini,Giuseppe Merla,Massimo Carella,Vito Michele Fazio,Paola Parrella +17 more
TL;DR: It is demonstrated thatKEAP1 is frequently methylated in malignant gliomas and a predictor of patient’s outcome and the results suggest that KEAP1 expression is epigenetically regulated.
Journal ArticleDOI
Aberrant Keap1 methylation in breast cancer and association with clinicopathological features.
Raffaela Barbano,Lucia Anna Muscarella,Barbara Pasculli,Vanna Maria Valori,Andrea Fontana,Michelina Coco,Annamaria la Torre,Teresa Balsamo,Maria Luana Poeta,Giovanni Francesco Marangi,Evaristo Maiello,Marina Castelvetere,Fabio Pellegrini,Roberto Murgo,Vito Michele Fazio,Paola Parrella +15 more
TL;DR: The results indicate that aberrant promoter methylation of the KEAP1 gene is involved in breast cancerogenesis, and identifying patients withKEAP1 epigenetic abnormalities may contribute to disease progression prediction in Breast cancer patients.
Journal ArticleDOI
A miRNA signature for defining aggressive phenotype and prognosis in gliomas.
Raffaela Barbano,Orazio Palumbo,Barbara Pasculli,Marco Galasso,Stefano Volinia,Vincenzo D'Angelo,Nadia Icolaro,Michelina Coco,Lucia Dimitri,Paolo Graziano,Massimiliano Copetti,Vanna Maria Valori,Evaristo Maiello,Massimo Carella,Vito Michele Fazio,Paola Parrella +15 more
TL;DR: A direct contribution of miRNAs to glioma cancerogenesis is supported and it is suggested that miR-21 andMiR-210 may play a role in the aggressive clinical behaviour of glioblastomas.
Journal ArticleDOI
Hypermethylated levels of E-cadherin promoter in Huh-7 cells expressing the HCV core protein.
Maria Ripoli,Raffaela Barbano,Teresa Balsamo,Claudia Piccoli,Virgilio Brunetti,Michelina Coco,Gianluigi Mazzoccoli,Manlio Vinciguerra,Valerio Pazienza +8 more
TL;DR: HCV core protein could play a role in HCC at least in part by altering the methylation status of CDH1 promoter, and these findings could also suggest a novel therapeutic approach for HCC.