C
Cynthia H. Collins
Researcher at Rensselaer Polytechnic Institute
Publications - 32
Citations - 3486
Cynthia H. Collins is an academic researcher from Rensselaer Polytechnic Institute. The author has contributed to research in topics: Quorum sensing & Synthetic biology. The author has an hindex of 19, co-authored 32 publications receiving 3168 citations. Previous affiliations of Cynthia H. Collins include University of Toronto & California Institute of Technology.
Papers
More filters
Journal ArticleDOI
A synthetic multicellular system for programmed pattern formation
TL;DR: A synthetic multicellular system in which genetically engineered ‘receiver’ cells are programmed to form ring-like patterns of differentiation based on chemical gradients of an acyl-homoserine lactone signal that is synthesized by ‘sender” cells is shown.
Journal ArticleDOI
A synthetic Escherichia coli predator-prey ecosystem.
Frederick K. Balagaddé,Frederick K. Balagaddé,Hao Song,Jun Ozaki,Cynthia H. Collins,Matthew Barnet,Frances H. Arnold,Stephen R. Quake,Lingchong You +8 more
TL;DR: A synthetic ecosystem consisting of two Escherichia coli populations, which communicate bi‐directionally through quorum sensing and regulate each other's gene expression and survival via engineered gene circuits is constructed, which resembles canonical predator–prey systems in terms of logic and dynamics.
Journal ArticleDOI
Modular optimization of multi-gene pathways for fatty acids production in E. coli
Peng Xu,Qin Gu,Wenya Wang,Wenya Wang,Lynn Wong,Adam G.W. Bower,Cynthia H. Collins,Mattheos A. G. Koffas +7 more
TL;DR: A modular engineering approach was systematically removed metabolic pathway bottlenecks and led to significant titre improvements in a multi-gene fatty acid metabolic pathway to demonstrate a generalized approach to engineering cell factories for valuable metabolites production.
Journal ArticleDOI
Towards synthetic microbial consortia for bioprocessing.
TL;DR: New methods, tools and opportunities that together have the potential to enable a new paradigm of bioprocessing using synthetic microbial consortia are outlined.
Journal ArticleDOI
Dual selection enhances the signaling specificity of a variant of the quorum-sensing transcriptional activator LuxR
TL;DR: A dual positive-negative selection system is used to identify a variant of LuxR-G2E that retains the response to straight-chain acyl-HSLs, but no longer responds to 3OC6HSL.