J
Jared R. Leadbetter
Researcher at California Institute of Technology
Publications - 68
Citations - 7642
Jared R. Leadbetter is an academic researcher from California Institute of Technology. The author has contributed to research in topics: Quorum sensing & Homoserine. The author has an hindex of 34, co-authored 68 publications receiving 7062 citations. Previous affiliations of Jared R. Leadbetter include Michigan State University & University of Iowa.
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Journal ArticleDOI
Metagenomic and functional analysis of hindgut microbiota of a wood-feeding higher termite.
Falk Warnecke,Peter Luginbuhl,Natalia Ivanova,Majid Ghassemian,Toby Richardson,Toby Richardson,Justin T. Stege,Michelle H. Cayouette,Alice C. McHardy,Gordana Djordjevic,Nahla Aboushadi,Rotem Sorek,Susannah G. Tringe,Mircea Podar,Hector Garcia Martin,Victor Kunin,Daniel Dalevi,Julita Madejska,Edward Kirton,Darren Platt,Ernest Szeto,Asaf Salamov,Kerrie Barry,Natalia Mikhailova,Nikos C. Kyrpides,Eric G. Matson,Elizabeth A. Ottesen,Xinning Zhang,Myriam Hernandez,Catalina Patricia Morales Murillo,Luis G. Acosta,Isidore Rigoutsos,Giselle Tamayo,Brian D. Green,Cathy Chang,Edward M. Rubin,Eric J. Mathur,Eric J. Mathur,Dan E. Robertson,Philip Hugenholtz,Jared R. Leadbetter +40 more
TL;DR: In this article, a metagenomic analysis of the bacterial community resident in the hindgut paunch of a wood-feeding Nasutitermes species (which do not contain cellulose-fermenting protozoa) was performed to show the presence of a large, diverse set of bacterial genes for cellulose and xylan hydrolysis.
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Microfluidic Digital PCR Enables Multigene Analysis of Individual Environmental Bacteria
TL;DR: A gene encoding a key enzyme involved in the mutualistic symbiosis occurring between termites and their gut microbiota was used as an experimental hook to discover the previously unknown ribosomal RNA–based species identity of several symbionts.
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Acyl‐homoserine lactone acylase from Ralstonia strain XJ12B represents a novel and potent class of quorum‐quenching enzymes
Yi-Han Lin,Jin-Ling Xu,Jiangyong Hu,Lian-Hui Wang,Say Leong Ong,Jared R. Leadbetter,Lian-Hui Zhang +6 more
TL;DR: LC‐MS analyses demonstrated that expression of AiiD in Pseudomonas aeruginosa PAO1 quenched quorum sensing by this bacterium, decreasing its ability to swarm, produce elastase and pyocyanin and to paralyse nematodes.
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Metabolism of Acyl-Homoserine Lactone Quorum-Sensing Signals by Variovorax paradoxus
TL;DR: This study indicates that some strains of V. paradoxus degrade and grow on acyl-HSL signals as the sole energy and nitrogen sources.
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Utilization of Acyl-Homoserine Lactone Quorum Signals for Growth by a Soil Pseudomonad and Pseudomonas aeruginosa PAO1
TL;DR: To the authors' knowledge, this is the first report of the degradation of AHLs by pseudomonads or other γ-Proteobacteria, of AHL acylase activity in a quorum-sensing bacterium, of HSL lacton enzyme activity in any bacterium and of AHL degradation with specificity only towards AHLs with long side chains.