C
Cynthia Osmanian
Researcher at Stanford University
Publications - 3
Citations - 2413
Cynthia Osmanian is an academic researcher from Stanford University. The author has contributed to research in topics: Apoptosis & Tumor suppressor gene. The author has an hindex of 3, co-authored 3 publications receiving 2368 citations.
Papers
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Journal ArticleDOI
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
Thomas G. Graeber,Cynthia Osmanian,Tyler Jacks,David E. Housman,Cameron J. Koch,Scott W. Lowe,Scott W. Lowe,Amato J. Giaccia +7 more
TL;DR: It is proposed that hypoxia provides a physiological selective pressure in tumours for the expansion of variants that have lost their apoptotic potential, and in particular for cells acquiring p53mutations.
Journal Article
Selection of human cervical epithelial cells that possess reduced apoptotic potential to low-oxygen conditions.
Charlotte Y. Kim,Mitchell H. Tsai,Cynthia Osmanian,Thomas G. Graeber,Jong Eun Lee,Rona G. Giffard,Joseph A. DiPaolo,Donna M. Peehl,Amato J. Giaccia +8 more
TL;DR: Evidence is provided for the role of hypoxia-mediated selection of cells with diminished apoptotic potential in the progression of human tumors and can in part explain why cervical tumors that possess low pO2 values are more aggressive.
Journal ArticleDOI
142 The role of hypoxia, p53, and apoptosis in human cervical carcinoma pathogenesis
Charlotte Y. Kim,Mitchell H. Tsai,Cynthia Osmanian,Dennise P. Calkins,Thomas G. Graeber,David L. Greenspan,Andrew S. Kennedy,Lillian H. Rinker,Mahesh A. Varia,Joseph A. DiPaolo,Donna M. Peehl,James A. Raleigh,Amato J. Giaccia +12 more