J
James A. Raleigh
Researcher at University of North Carolina at Chapel Hill
Publications - 89
Citations - 8759
James A. Raleigh is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Pimonidazole & Tumor hypoxia. The author has an hindex of 49, co-authored 89 publications receiving 8452 citations.
Papers
More filters
Journal ArticleDOI
ER stress‐regulated translation increases tolerance to extreme hypoxia and promotes tumor growth
Meixia Bi,Christine Naczki,Marianne Koritzinsky,Diane Fels,Jaime D. Blais,Nianping Hu,Heather P. Harding,Isabelle Novoa,Mahesh A. Varia,James A. Raleigh,Donalyn Scheuner,Randal J. Kaufman,John C. Bell,David Ron,Bradly G. Wouters,Constantinos Koumenis +15 more
TL;DR: It is demonstrated that cells cultured under hypoxic/anoxic conditions and transformed cells in hypoxic areas of tumors activate a translational control program known as the integrated stress response (ISR), which adapts cells to endoplasmic reticulum (ER) stress and suggests that this pathway is an attractive target for antitumor modalities.
Journal ArticleDOI
Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates.
Laura E. Via,P. Ling Lin,Sonja M. Ray,Jose Carrillo,Shannon Sedberry Allen,Seok Yong Eum,Kimberly L. Taylor,Edwin Klein,Ujjini H. Manjunatha,Jacqueline Gonzales,Eun Gae Lee,Seung Kyu Park,James A. Raleigh,Sang Nae Cho,David N. McMurray,JoAnne L. Flynn,Clifton E. Barry +16 more
TL;DR: Three independent lines of evidence support the hypothesis that hypoxic microenvironments are an important feature of some lesions in these animal models of tuberculosis.
Journal Article
Pimonidazole Binding and Tumor Vascularity Predict for Treatment Outcome in Head and Neck Cancer
Johannes H.A.M. Kaanders,Karien I.E.M. Wijffels,Henri A. M. Marres,Anna S. E. Ljungkvist,Lucas A.M. Pop,Franciscus J.A. van den Hoogen,Peter C.M. de Wilde,Johan Bussink,James A. Raleigh,Albert J. van der Kogel +9 more
TL;DR: It is concluded that pimonidazole binding and vascular density can predict treatment outcome in head and neck cancer and may be useful as selection tools for hypoxia-modifying treatments.
Journal ArticleDOI
Pimonidazole: A novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma
Mahesh A. Varia,Dennise P. Calkins-Adams,Lillian H. Rinker,Andrew S. Kennedy,Debra B. Novotny,Wesley C. Fowler,James A. Raleigh +6 more
TL;DR: Pimonidazole can be used for qualitative and quantitative assessment of tumor hypoxia, and immunostaining with pimonidrazole antibody was observed in 9 of 10 tumors, suggesting thatHypoxia is a common occurrence in cervical carcinoma.
Journal ArticleDOI
Evidence that hypoxia markers detect oxygen gradients in liver: pimonidazole and retrograde perfusion of rat liver.
TL;DR: It is concluded that low oxygen concentration rather than the non-homogeneous distribution of nitroreductase activity is the primary determinant of 2-nitroimidazole binding in liver.