M
Mahesh A. Varia
Researcher at University of North Carolina at Chapel Hill
Publications - 84
Citations - 5282
Mahesh A. Varia is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Radiation therapy & Pimonidazole. The author has an hindex of 36, co-authored 84 publications receiving 4976 citations.
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Journal ArticleDOI
ER stress‐regulated translation increases tolerance to extreme hypoxia and promotes tumor growth
Meixia Bi,Christine Naczki,Marianne Koritzinsky,Diane Fels,Jaime D. Blais,Nianping Hu,Heather P. Harding,Isabelle Novoa,Mahesh A. Varia,James A. Raleigh,Donalyn Scheuner,Randal J. Kaufman,John C. Bell,David Ron,Bradly G. Wouters,Constantinos Koumenis +15 more
TL;DR: It is demonstrated that cells cultured under hypoxic/anoxic conditions and transformed cells in hypoxic areas of tumors activate a translational control program known as the integrated stress response (ISR), which adapts cells to endoplasmic reticulum (ER) stress and suggests that this pathway is an attractive target for antitumor modalities.
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Consensus guidelines for delineation of clinical target volume for intensity-modulated pelvic radiotherapy in postoperative treatment of endometrial and cervical cancer.
William Small,Loren K. Mell,Penny R. Anderson,Carien L. Creutzberg,Jennifer F. De Los Santos,David K. Gaffney,Anuja Jhingran,Lorraine Portelance,Tracey E. Schefter,Revathy B. Iyer,Mahesh A. Varia,Kathryn Winter,Arno J. Mundt +12 more
TL;DR: An atlas of the clinical target volume definitions for postoperative radiotherapy of endometrial and cervical cancer to be used for planning pelvic intensity-modulated radiotherapy serves as an international template for the definition of the CTV.
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Pimonidazole: A novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma
Mahesh A. Varia,Dennise P. Calkins-Adams,Lillian H. Rinker,Andrew S. Kennedy,Debra B. Novotny,Wesley C. Fowler,James A. Raleigh +6 more
TL;DR: Pimonidazole can be used for qualitative and quantitative assessment of tumor hypoxia, and immunostaining with pimonidrazole antibody was observed in 9 of 10 tumors, suggesting thatHypoxia is a common occurrence in cervical carcinoma.
Journal Article
Hypoxia and vascular endothelial growth factor expression in human squamous cell carcinomas using pimonidazole as a hypoxia marker
James A. Raleigh,Dennise P. Calkins-Adams,Lillian H. Rinker,Cynthia A. Ballenger,Mark C. Weissler,Wesley C. Fowler,Debra B. Novotny,Mahesh A. Varia +7 more
TL;DR: A quantitative immunohistochemical comparison of hypoxia and VEGF protein expression revealed no correlation between the two factors, and the hypothesis that hypoxIA and V EGFprotein expression are coupled in human tumors was tested.
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Proposed guidelines for image-based intracavitary brachytherapy for cervical carcinoma: Report from Image-Guided Brachytherapy Working Group
Subir Nag,Higinia R. Cardenes,Silvia D. Chang,Silvia D. Chang,Indra J. Das,Indra J. Das,Beth Erickson,Geoffrey S. Ibbott,Jessica Lowenstein,J. Roll,Bruce R. Thomadsen,Bruce R. Thomadsen,Mahesh A. Varia +12 more
TL;DR: Although current institutional brachytherapy prescription for cervical cancer should continue, image-based data collection and analysis are needed to optimize cervical cancer brachyTherapy.