D
D. Rovito
Researcher at University of Strasbourg
Publications - 4
Citations - 39
D. Rovito is an academic researcher from University of Strasbourg. The author has contributed to research in topics: Calcitriol receptor & Promoter. The author has an hindex of 2, co-authored 4 publications receiving 18 citations. Previous affiliations of D. Rovito include University of Calabria.
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Journal ArticleDOI
Conditional expression of Ki-RasG12V in the mammary epithelium of transgenic mice induces estrogen receptor alpha (ERα)-positive adenocarcinoma.
S. Andò,Rocco Malivindi,Stefania Catalano,Pietro Rizza,Ines Barone,Salvatore Panza,D. Rovito,D. Rovito,Emprou C,Bornert Jm,Gilles Laverny,Daniel Metzger +11 more
TL;DR: The mammary tumors of this transgenic mouse line expressing the human Ki-Ras bearing an activating mutation selectively in the mammary epithelium after lactation exhibit key features of the major form of human breast cancer, that is, luminal A subtype and thus have a high potential for breast cancer research and treatment.
Journal ArticleDOI
Structural Analysis of VDR Complex with ZK168281 Antagonist
TL;DR: The crystal structure of the zebrafish VDR ligand binding domain in complex with the ZK168281 antagonist reveals that the ligand prevents optimal folding of the C-terminal region of VDR.
Journal ArticleDOI
Cytosolic sequestration of the vitamin D receptor as a therapeutic option for vitamin D-induced hypercalcemia.
D. Rovito,Anna Y. Belorusova,Sandra Chalhoub,Anna-Isavella Rerra,Elvire Guiot,Arnaud Molin,Agnès Linglart,Natacha Rochel,Gilles Laverny,Daniel Metzger +9 more
TL;DR: WBP4 is identified as a new VDR interactant, and it is demonstrated that it controls VDR subcellular localization, and the vitamin D analogue ZK168281 enhances the interaction between VDR and WBP4 in the cytosol, and normalizes the expression of VDR target genes and serum calcium levels in 1α,25(OH)2D3-intoxicated mice.
Journal ArticleDOI
Myod1 and GR coordinate myofiber-specific transcriptional enhancers.
D. Rovito,Anna-Isavella Rerra,Vanessa Ueberschlag-Pitiot,Shilpy Joshi,Nezih Karasu,Vanessa Dacleu-Siewe,Khalil Ben Rayana,Kamar Ghaibour,Maxime Parisotto,Arnaud Ferry,Scott A. Jelinsky,Gilles Laverny,Bruno P. Klaholz,Tom Sexton,Isabelle M. L. Billas,Delphine Duteil,Daniel Metzger +16 more
TL;DR: In this paper, the authors investigated the skeletal muscle transcriptional program and identified key tissue-specific regulatory genetic elements, such as Myod1, GR and Nrf1, for myofiber size regulation.