Rocco Malivindi

TL;DR: Results support the hypothesis that STAT3 and CREB play an important role in leptin signaling pathway that leads to the proliferation of Ishikawa cells, thus establishing a direct association between obesity and endometrial tumorogenesis.

TL;DR: Androgens control perineal and limb muscle mass in male mice through myocytic AR-dependent and -independent pathways, respectively, which may allow the design of screens to identify selective androgen modulators of muscle strength.

TL;DR: It is shown, for the first time, that tyrosine phosphorylation processes play a key role in the rapid changes induced by E2 in aromatase enzymatic activity, revealing the existence of a short nongenomic autocrine loop between E2 and aromat enzyme in breast cancer cells.

TL;DR: One of the molecular mechanisms determining Leydig cell tumorigenesis is an excessive estrogen production that stimulates a short autocrine loop determining cell proliferation.

TL;DR: It is found that FXR activation by the primary bile acid chenodeoxycholic acid or a synthetic agonist GW4064, through a SHP-independent mechanism, down-regulates aromatase expression in terms of mRNA, protein levels, and its enzymatic activity.