D
D Tozer
Researcher at University of Cambridge
Publications - 26
Citations - 679
D Tozer is an academic researcher from University of Cambridge. The author has contributed to research in topics: Vascular dementia & Dementia. The author has an hindex of 10, co-authored 26 publications receiving 345 citations. Previous affiliations of D Tozer include St George's, University of London & University College Hospital.
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Journal ArticleDOI
Genetic variation in PLEKHG1 is associated with white matter hyperintensities (n = 11,226)
Matthew Traylor,D Tozer,Iain D. Croall,Danuta M. Lisiecka Ford,Abiodun Olubunmi Olorunda,Giorgio B. Boncoraglio,Martin Dichgans,Robin Lemmens,Jonathan Rosand,Natalia S. Rost,Peter M. Rothwell,Cathie Sudlow,Vincent Thijs,Vincent Thijs,Loes C.A. Rutten-Jacobs,Hugh S. Markus +15 more
TL;DR: Genetic variation in PLEKHG1 is associated with WMH and ischemic stroke, most strongly with the small vessel subtype, suggesting it acts by promoting small vessel arteriopathy.
Journal ArticleDOI
Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies.
Matthew Traylor,Elodie Persyn,Liisa Tomppo,Sofia Klasson,Vida Abedi,Mark K Bakker,Nuria Torres,Linxin Li,Steven Bell,Loes Rutten-Jacobs,D Tozer,Christoph J. Griessenauer,Yanfei Zhang,Annie Pedersen,Pankaj Sharma,Jordi Jimenez-Conde,Tatjana Rundek,Raji P. Grewal,Arne Lindgren,James F. Meschia,Veikko Salomaa,Aki S. Havulinna,Christina Kourkoulis,Katherine Crawford,Sandro Marini,Braxton D. Mitchell,Steven J. Kittner,Jonathan Rosand,Martin Dichgans,Christina Jern,Daniel Strbian,Israel Fernandez-Cadenas,Ramin Zand,Ynte M. Ruigrok,Natalia S. Rost,Robin Lemmens,Peter M. Rothwell,Christopher D. Anderson,Joanna M. Wardlaw,Cathryn M. Lewis,Hugh S. Markus,UK Dna Lacunar Stroke Study Investigators +41 more
TL;DR: In this paper, a pooled analysis of data from newly recruited patients with an MRI-confirmed diagnosis of lacunar stroke and existing genome-wide association studies (GWAS) was performed to identify novel associations and provide mechanistic insights into the disease.
Journal ArticleDOI
Using DTI to assess white matter microstructure in cerebral small vessel disease (SVD) in multicentre studies.
Iain D. Croall,Lohner,Barry Moynihan,Usman A. Khan,Ahamad Hassan,John T. O'Brien,Robin G. Morris,D Tozer,Victoria C. Cambridge,K Harkness,David J. Werring,Andrew M. Blamire,Gary A. Ford,Thomas R. Barrick,Hugh S. Markus +14 more
TL;DR: In this article, a multicentre study confirmed associations between fractional anisotropy (FA) and mean diffusivity (MD) metrics and cognition in a multiantire setting.
Journal ArticleDOI
Effect of Standard vs Intensive Blood Pressure Control on Cerebral Blood Flow in Small Vessel Disease: The PRESERVE Randomized Clinical Trial.
Iain D. Croall,D Tozer,Barry Moynihan,Usman Khan,John T. O'Brien,Robin G. Morris,Victoria C. Cambridge,Thomas R. Barrick,Andrew M. Blamire,Gary A. Ford,Hugh S. Markus +10 more
TL;DR: Intensive BP lowering did not reduce cerebral perfusion in severe small vessel disease and no differences were observed when the analysis examined gray or white matter only or was confined to those achieving target BP.
Journal ArticleDOI
Genetic Study of White Matter Integrity in UK Biobank (N=8448) and the Overlap With Stroke, Depression, and Dementia.
Loes C.A. Rutten-Jacobs,Loes C.A. Rutten-Jacobs,D Tozer,Marco Duering,Rainer Malik,Martin Dichgans,Hugh S. Markus,Matthew Traylor +7 more
TL;DR: Genetic variants within the VCAN gene may play a role in the mechanisms underlying microstructural integrity of the white matter in the brain measured as FA and MD.