M
Matthew Traylor
Researcher at Queen Mary University of London
Publications - 117
Citations - 8817
Matthew Traylor is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Genome-wide association study & Stroke. The author has an hindex of 37, co-authored 105 publications receiving 6350 citations. Previous affiliations of Matthew Traylor include Boston University & King's College London.
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Journal ArticleDOI
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
Naomi R. Wray,Stephan Ripke,Stephan Ripke,Stephan Ripke,Manuel Mattheisen,Maciej Trzaskowski,Enda M. Byrne,Abdel Abdellaoui,Mark Adams,Esben Agerbo,Esben Agerbo,Tracy Air,Till M.F. Andlauer,Silviu Alin Bacanu,Marie Bækvad-Hansen,Marie Bækvad-Hansen,Aartjan F.T. Beekman,Tim B. Bigdeli,Elisabeth B. Binder,Elisabeth B. Binder,Douglas Blackwood,Julien Bryois,Henriette N. Buttenschøn,Henriette N. Buttenschøn,Jonas Bybjerg-Grauholm,Jonas Bybjerg-Grauholm,Na Cai,Na Cai,Enrique Castelao,Jane H. Christensen,Jane H. Christensen,Toni-Kim Clarke,Jonathan I.R. Coleman,Lucía Colodro-Conde,Baptiste Couvy-Duchesne,Nicholas John Craddock,Gregory E. Crawford,Cheynna A. Crowley,Hassan S. Dashti,Hassan S. Dashti,Gail Davies,Ian J. Deary,Franziska Degenhardt,Eske M. Derks,Nese Direk,Nese Direk,Conor V. Dolan,Erin C. Dunn,Erin C. Dunn,Thalia C. Eley,Nicholas Eriksson,Valentina Escott-Price,Farnush Hassan Farhadi Kiadeh,Hilary K. Finucane,Hilary K. Finucane,Andreas J. Forstner,Josef Frank,Helena Gaspar,Michael Gill,Paola Giusti-Rodríguez,Fernando S. Goes,Scott D. Gordon,Jakob Grove,Lynsey S. Hall,Lynsey S. Hall,Eilis Hannon,Christine Søholm Hansen,Christine Søholm Hansen,Thomas Hansen,Thomas Hansen,Stefan Herms,Stefan Herms,Ian B. Hickie,Per Hoffmann,Per Hoffmann,Georg Homuth,Carsten Horn,Jouke-Jan Hottenga,David M. Hougaard,David M. Hougaard,Ming Hu,Craig L. Hyde,Marcus Ising,Rick Jansen,Fulai Jin,Eric Jorgenson,James A. Knowles,Isaac S. Kohane,Isaac S. Kohane,Isaac S. Kohane,Julia Kraft,Warren W. Kretzschmar,Jesper Krogh,Zoltán Kutalik,Zoltán Kutalik,Jacqueline M. Lane,Jacqueline M. Lane,Yihan Li,Yun Li,Penelope A. Lind,Xiaoxiao Liu,Leina Lu,Donald J. MacIntyre,Dean F. MacKinnon,Robert Maier,Wolfgang Maier,Jonathan Marchini,Hamdi Mbarek,Patrick J. McGrath,Peter McGuffin,Sarah E. Medland,Divya Mehta,Divya Mehta,Christel M. Middeldorp,Christel M. Middeldorp,Evelin Mihailov,Yuri Milaneschi,Lili Milani,Jonathan Mill,Francis M. Mondimore,Grant W. Montgomery,Sara Mostafavi,Niamh Mullins,Matthias Nauck,Bernard Ng,Michel G. Nivard,Dale R. Nyholt,Paul F. O'Reilly,Hogni Oskarsson,Michael John Owen,Jodie N. Painter,Carsten Bøcker Pedersen,Carsten Bøcker Pedersen,Marianne Giørtz Pedersen,Marianne Giørtz Pedersen,Roseann E. Peterson,Erik Pettersson,Wouter J. Peyrot,Giorgio Pistis,Danielle Posthuma,Shaun Purcell,Jorge A. Quiroz,Per Qvist,Per Qvist,John P. Rice,Brien P. Riley,Margarita Rivera,Margarita Rivera,Saira Saeed Mirza,Richa Saxena,Richa Saxena,Robert A. Schoevers,Eva C. Schulte,Ling Shen,Jianxin Shi,Stanley I. Shyn,Engilbert Sigurdsson,Grant Sinnamon,Johannes H. Smit,Daniel J. Smith,Hreinn Stefansson,Stacy Steinberg,Craig A. Stockmeier,Fabian Streit,Jana Strohmaier,Katherine E. Tansey,Henning Teismann,Alexander Teumer,Wesley K. Thompson,Pippa A. Thomson,Thorgeir E. Thorgeirsson,Chao Tian,Matthew Traylor,Jens Treutlein,Vassily Trubetskoy,André G. Uitterlinden,Daniel Umbricht,Sandra Van der Auwera,Albert M. van Hemert,Alexander Viktorin,Peter M. Visscher,Yunpeng Wang,Yunpeng Wang,Yunpeng Wang,Bradley T. Webb,Shantel Weinsheimer,Shantel Weinsheimer,Jürgen Wellmann,Gonneke Willemsen,Stephanie H. Witt,Yang Wu,Hualin S. Xi,Jian Yang,Futao Zhang,Volker Arolt,Bernhard T. Baune,Klaus Berger,Dorret I. Boomsma,Sven Cichon,Udo Dannlowski,E. C.J. De Geus,J. Raymond DePaulo,Enrico Domenici,Katharina Domschke,Tõnu Esko,Tõnu Esko,Hans J. Grabe,Steven P. Hamilton,Caroline Hayward,Andrew C. Heath,David A. Hinds,Kenneth S. Kendler,Stefan Kloiber,Stefan Kloiber,Stefan Kloiber,Glyn Lewis,Qingqin S. Li,Susanne Lucae,Pamela F.A. Madden,Patrik K. E. Magnusson,Nicholas G. Martin,Andrew M. McIntosh,Andres Metspalu,Ole Mors,Ole Mors,Preben Bo Mortensen,Bertram Müller-Myhsok,Bertram Müller-Myhsok,Merete Nordentoft,Merete Nordentoft,Markus M. Nöthen,Michael Conlon O'Donovan,Sara A. Paciga,Nancy L. Pedersen,Brenda W.J.H. Penninx,Roy H. Perlis,David J. Porteous,James B. Potash,Martin Preisig,Marcella Rietschel,Catherine Schaefer,Thomas G. Schulze,Jordan W. Smoller,Jordan W. Smoller,Kari Stefansson,Kari Stefansson,Henning Tiemeier,Rudolf Uher,Henry Völzke,Myrna M. Weissman,Myrna M. Weissman,Thomas Werge,Thomas Werge,Thomas Werge,Ashley R. Winslow,Ashley R. Winslow,Cathryn M. Lewis,Douglas F. Levinson,Gerome Breen,Anders D. Børglum,Anders D. Børglum,Patrick F. Sullivan,Patrick F. Sullivan +262 more
TL;DR: A genome-wide association meta-analysis of individuals with clinically assessed or self-reported depression identifies 44 independent and significant loci and finds important relationships of genetic risk for major depression with educational attainment, body mass, and schizophrenia.
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
Rainer Malik,Ganesh Chauhan,Matthew Traylor,Muralidharan Sargurupremraj,Yukinori Okada,Aniket Mishra,Loes C.A. Rutten-Jacobs,Anne-Katrin Giese,Sander W. van der Laan,Solveig Gretarsdottir,Christopher D. Anderson,Michael Chong,Hieab H.H. Adams,Tetsuro Ago,Peter Almgren,Philippe Amouyel,Hakan Ay,Traci M. Bartz,Oscar R. Benavente,Steve Bevan,Giorgio B. Boncoraglio,Robert D. Brown,Adam S. Butterworth,Caty Carrera,Cara L. Carty,Daniel I. Chasman,Wei-Min Chen,John W. Cole,Adolfo Correa,Ioana Cotlarciuc,Carlos Cruchaga,John Danesh,Paul I.W. de Bakker,Anita L. DeStefano,Marcel den Hoed,Qing Duan,Stefan T. Engelter,Guido J. Falcone,Rebecca F. Gottesman,Raji P. Grewal,Vilmundur Gudnason,Stefan Gustafsson,Jeffrey Haessler,Tamara B. Harris,Ahamad Hassan,Aki S. Havulinna,Susan R. Heckbert,Elizabeth G. Holliday,George Howard,Fang-Chi Hsu,Hyacinth I. Hyacinth,M. Arfan Ikram,Erik Ingelsson,Marguerite R. Irvin,Xueqiu Jian,Jordi Jimenez-Conde,Julie A. Johnson,J. Wouter Jukema,Masahiro Kanai,Keith L. Keene,Brett M. Kissela,Dawn Kleindorfer,Charles Kooperberg,Michiaki Kubo,Leslie A. Lange,Carl D. Langefeld,Claudia Langenberg,Lenore J. Launer,Jin-Moo Lee,Robin Lemmens,Didier Leys,Cathryn M. Lewis,Wei-Yu Lin,Arne Lindgren,Erik Lorentzen,Patrik K. E. Magnusson,Jane Maguire,Ani Manichaikul,Patrick F. McArdle,James F. Meschia,Braxton D. Mitchell,Thomas H. Mosley,Mike A. Nalls,Toshiharu Ninomiya,Martin O'Donnell,Bruce M. Psaty,Sara L. Pulit,Kristiina Rannikmäe,Alexander P. Reiner,Kathryn M. Rexrode,Kenneth Rice,Stephen S. Rich,Paul M. Ridker,Natalia S. Rost,Peter M. Rothwell,Jerome I. Rotter,Tatjana Rundek,Ralph L. Sacco,Saori Sakaue,Michèle M. Sale,Veikko Salomaa,Bishwa Raj Sapkota,Reinhold Schmidt,Carsten Oliver Schmidt,Ulf Schminke,Pankaj Sharma,Agnieszka Slowik,Cathie Sudlow,Christian Tanislav,Turgut Tatlisumak,Kent D. Taylor,Vincent Thijs,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Steffen Tiedt,Stella Trompet,Christophe Tzourio,Cornelia M. van Duijn,Matthew Walters,Nicholas J. Wareham,Sylvia Wassertheil-Smoller,James G. Wilson,Kerri L. Wiggins,Qiong Yang,Salim Yusuf,Joshua C. Bis,Tomi Pastinen,Arno Ruusalepp,Eric E. Schadt,Simon Koplev,Johan Björkegren,Veronica Codoni,Mete Civelek,Nicholas L. Smith,David A. Tregouet,Ingrid E. Christophersen,Carolina Roselli,Steven A. Lubitz,Patrick T. Ellinor,E. Shyong Tai,Jaspal S. Kooner,Norihiro Kato,Jiang He,Pim van der Harst,Paul Elliott,John C. Chambers,Fumihiko Takeuchi,Andrew D. Johnson,Dharambir K. Sanghera,Olle Melander,Christina Jern,Daniel Strbian,Israel Fernandez-Cadenas,W. T. Longstreth,Arndt Rolfs,Jun Hata,Daniel Woo,Jonathan Rosand,Guillaume Paré,Jemma C. Hopewell,Danish Saleheen,Kari Stefansson,Bradford B. Worrall,Steven J. Kittner,Sudha Seshadri,Myriam Fornage,Hugh S. Markus,Joanna M. M. Howson,Yoichiro Kamatani,Stéphanie Debette,Martin Dichgans +170 more
TL;DR: A multiancestry genome-wide-association meta-analysis and discovered 22 new stroke risk loci, indicating mechanisms not previously implicated in stroke pathophysiology, with prioritization of risk variants and genes accomplished through bioinformatics analyses using extensive functional datasets.
Journal ArticleDOI
Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies.
Matthew Traylor,Martin Farrall,Elizabeth G. Holliday,Cathie Sudlow,Jemma C. Hopewell,Yu-Ching Cheng,Myriam Fornage,M. Arfan Ikram,Rainer Malik,Steve Bevan,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Mike A. Nalls,W. T. Longstreth,Kerri L. Wiggins,Sunaina Yadav,Eugenio Parati,Anita L. DeStefano,Bradford B. Worrall,Steven J. Kittner,Muhammad Saleem Khan,Alexander P. Reiner,Anna Helgadottir,Anna Helgadottir,Anna Helgadottir,Sefanja Achterberg,Israel Fernandez-Cadenas,Sherine Abboud,Reinhold Schmidt,Matthew Walters,Wei-Min Chen,Wei-Min Chen,E. Bernd Ringelstein,Martin O'Donnell,Weang Kee Ho,Joanna Pera,Robin Lemmens,Bo Norrving,Peter Higgins,Marianne Benn,Michèle M. Sale,Gregor Kuhlenbäumer,Alex S. F. Doney,Astrid M. Vicente,Hossein Delavaran,Ale Algra,Gail Davies,Sofia A. Oliveira,Colin N. A. Palmer,Ian C. Deary,Helena Schmidt,Massimo Pandolfo,Joan Montaner,Cara L. Carty,Paul I.W. de Bakker,Paul I.W. de Bakker,Paul I.W. de Bakker,Konstantinos Kostulas,José M. Ferro,Natalie R. van Zuydam,Einar M. Valdimarsson,Børge G. Nordestgaard,Arne Lindgren,Vincent Thijs,Agnieszka Slowik,Danish Saleheen,Danish Saleheen,Guillaume Paré,Klaus Berger,Gudmar Thorleifsson,Albert Hofman,Thomas H. Mosley,Braxton D. Mitchell,Karen L. Furie,Robert Clarke,Christopher R Levi,Sudha Seshadri,Andreas Gschwendtner,Giorgio B. Boncoraglio,Pankaj Sharma,Joshua C. Bis,Solveig Gretarsdottir,Bruce M. Psaty,Peter M. Rothwell,Jonathan Rosand,Jonathan Rosand,Jonathan Rosand,James F. Meschia,Kari Stefansson,Kari Stefansson,Martin Dichgans,Hugh S. Markus +91 more
TL;DR: The results show that, although genetic variants can be detected in patients with ischaemic stroke when compared with controls, all associations validated are specific to a stroke subtype, and this finding has two implications.
Journal ArticleDOI
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke
Céline Bellenguez,Steve Bevan,Andreas Gschwendtner,Spencer Cca.,Annette I. Burgess,Matti Pirinen,Caroline A. Jackson,Matthew Traylor,Amy Strange,Zhan Su,P D Syme,Rainer Malik,Joanna Pera,N. Bo,Robin Lemmens,Robin Lemmens,Colin Freeman,R. Schanz,T James,D Poole,Lee Murphy,Helen Segal,L Cortellini,Cheng Y-C.,Daniel Woo,Mike A. Nalls,Bertram Müller-Myhsok,Christa Meisinger,Udo Seedorf,Helen Ross-Adams,Steven Boonen,D. Wloch-Kopec,V Valant,Julia Slark,Karen L. Furie,Hossein Delavaran,Cordelia Langford,Panos Deloukas,Sarah Edkins,Sarah E. Hunt,Emma Gray,Serge Dronov,Leena Peltonen,Solveig Gretarsdottir,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson,Giorgio B. Boncoraglio,Eugenio Parati,John Attia,Elizabeth G. Holliday,Christopher R Levi,Franzosi M-G.,Anuj Goel,Anna Helgadottir,Anna Helgadottir,Jenefer M. Blackwell,Jenefer M. Blackwell,Elvira Bramon,Matthew A. Brown,Juan P. Casas,Juan P. Casas,Aiden Corvin,Audrey Duncanson,Janusz Jankowski,Janusz Jankowski,Christopher G. Mathew,Palmer Cna.,Robert Plomin,Anna Rautanen,Stephen Sawcer,Richard C. Trembath,Ananth C. Viswanathan,Nicholas W. Wood,B. B. Worrall,Steven J. Kittner,Steven J. Kittner,Braxton D. Mitchell,Brett M. Kissela,James F. Meschia,Vincent Thijs,Vincent Thijs,Arne Lindgren,Mary Joan MacLeod,Agnieszka Slowik,Matthew Walters,Jonathan Rosand,Jonathan Rosand,Pankaj Sharma,Martin Farrall,Sudlow Clm.,Peter M. Rothwell,Martin Dichgans,Peter Donnelly,Hugh S. Markus +96 more
TL;DR: A new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21.1 is identified, which suggests distinct genetic architectures for different stroke subtypes.
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke
Céline Bellenguez,Steve Bevan,Andreas Gschwendtner,Chris C. A. Spencer,Annette I. Burgess,Matti Pirinen,Caroline A. Jackson,Matthew Traylor,A. Strange,Zhan Su,Paul D. Syme,Rainer Malik,Joanna Pera,N. Bo,Robin Lemmens,Colin Freeman,R. Schanz,Terena James,D Poole,Lee Murphy,Helen Segal,Lynelle Cortellini,Yu-Ching Cheng,Daniel Woo,Mike A. Nalls,Bertram Müller-Myhsok,Christa Meisinger,Udo Seedorf,Helen Ross-Adams,Steven Boonen,D. Wloch-Kopec,Valerie Valant,Julia Slark,K. L. Furie,Hossein Delavaran,Cordelia Langford,Panos Deloukas,Sarah Edkins,Sarah E. Hunt,Erin Gray,Serge Dronov,Leena Peltonen,Solveig Gretarsdottir,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Kari Stefansson,Giorgio B. Boncoraglio,Eugenio Parati,John Attia,Elizabeth G. Holliday,Christopher R Levi,MariaGrazia Franzosi,Anuj Goel,Anna Helgadottir,Jenefer M. Blackwell,Elvira Bramon,Matthew A. Brown,Juan P. Casas,Aiden Corvin,Audrey Duncanson,Janusz Jankowski,Christopher G. Mathew,Colin N. A. Palmer,Robert Plomin,Anna Rautanen,Stephen Sawcer,Richard C. Trembath,Anand Viswanathan,Nicholas W. Wood,B. B. Worrall,Steven J. Kittner,Braxton D. Mitchell,Brett M. Kissela,James F. Meschia,Vincent Thijs,Arne Lindgren,Mary Joan MacLeod,Agnieszka Slowik,Matthew Walters,Jonathan Rosand,Pankaj Sharma,Martin Farrall,Cathie Sudlow,Peter M. Rothwell,Martin Dichgans,Peter Donnelly,Hugh S. Markus +86 more
TL;DR: The authors conducted a genome-wide association study (GWAS) for ischemic stroke and its subtypes in 3,548 affected individuals and 5,972 controls, all of European ancestry, and identified a new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21.