R
Raji P. Grewal
Researcher at St. Francis Medical Center
Publications - 49
Citations - 1596
Raji P. Grewal is an academic researcher from St. Francis Medical Center. The author has contributed to research in topics: Stroke & Population. The author has an hindex of 12, co-authored 49 publications receiving 1109 citations. Previous affiliations of Raji P. Grewal include Seton Hall University.
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Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
Rainer Malik,Ganesh Chauhan,Matthew Traylor,Muralidharan Sargurupremraj,Yukinori Okada,Aniket Mishra,Loes C.A. Rutten-Jacobs,Anne-Katrin Giese,Sander W. van der Laan,Solveig Gretarsdottir,Christopher D. Anderson,Michael Chong,Hieab H.H. Adams,Tetsuro Ago,Peter Almgren,Philippe Amouyel,Hakan Ay,Traci M. Bartz,Oscar R. Benavente,Steve Bevan,Giorgio B. Boncoraglio,Robert D. Brown,Adam S. Butterworth,Caty Carrera,Cara L. Carty,Daniel I. Chasman,Wei-Min Chen,John W. Cole,Adolfo Correa,Ioana Cotlarciuc,Carlos Cruchaga,John Danesh,Paul I.W. de Bakker,Anita L. DeStefano,Marcel den Hoed,Qing Duan,Stefan T. Engelter,Guido J. Falcone,Rebecca F. Gottesman,Raji P. Grewal,Vilmundur Gudnason,Stefan Gustafsson,Jeffrey Haessler,Tamara B. Harris,Ahamad Hassan,Aki S. Havulinna,Susan R. Heckbert,Elizabeth G. Holliday,George Howard,Fang-Chi Hsu,Hyacinth I. Hyacinth,M. Arfan Ikram,Erik Ingelsson,Marguerite R. Irvin,Xueqiu Jian,Jordi Jimenez-Conde,Julie A. Johnson,J. Wouter Jukema,Masahiro Kanai,Keith L. Keene,Brett M. Kissela,Dawn Kleindorfer,Charles Kooperberg,Michiaki Kubo,Leslie A. Lange,Carl D. Langefeld,Claudia Langenberg,Lenore J. Launer,Jin-Moo Lee,Robin Lemmens,Didier Leys,Cathryn M. Lewis,Wei-Yu Lin,Arne Lindgren,Erik Lorentzen,Patrik K. E. Magnusson,Jane Maguire,Ani Manichaikul,Patrick F. McArdle,James F. Meschia,Braxton D. Mitchell,Thomas H. Mosley,Mike A. Nalls,Toshiharu Ninomiya,Martin O'Donnell,Bruce M. Psaty,Sara L. Pulit,Kristiina Rannikmäe,Alexander P. Reiner,Kathryn M. Rexrode,Kenneth Rice,Stephen S. Rich,Paul M. Ridker,Natalia S. Rost,Peter M. Rothwell,Jerome I. Rotter,Tatjana Rundek,Ralph L. Sacco,Saori Sakaue,Michèle M. Sale,Veikko Salomaa,Bishwa Raj Sapkota,Reinhold Schmidt,Carsten Oliver Schmidt,Ulf Schminke,Pankaj Sharma,Agnieszka Slowik,Cathie Sudlow,Christian Tanislav,Turgut Tatlisumak,Kent D. Taylor,Vincent Thijs,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Steffen Tiedt,Stella Trompet,Christophe Tzourio,Cornelia M. van Duijn,Matthew Walters,Nicholas J. Wareham,Sylvia Wassertheil-Smoller,James G. Wilson,Kerri L. Wiggins,Qiong Yang,Salim Yusuf,Joshua C. Bis,Tomi Pastinen,Arno Ruusalepp,Eric E. Schadt,Simon Koplev,Johan Björkegren,Veronica Codoni,Mete Civelek,Nicholas L. Smith,David A. Tregouet,Ingrid E. Christophersen,Carolina Roselli,Steven A. Lubitz,Patrick T. Ellinor,E. Shyong Tai,Jaspal S. Kooner,Norihiro Kato,Jiang He,Pim van der Harst,Paul Elliott,John C. Chambers,Fumihiko Takeuchi,Andrew D. Johnson,Dharambir K. Sanghera,Olle Melander,Christina Jern,Daniel Strbian,Israel Fernandez-Cadenas,W. T. Longstreth,Arndt Rolfs,Jun Hata,Daniel Woo,Jonathan Rosand,Guillaume Paré,Jemma C. Hopewell,Danish Saleheen,Kari Stefansson,Bradford B. Worrall,Steven J. Kittner,Sudha Seshadri,Myriam Fornage,Hugh S. Markus,Joanna M. M. Howson,Yoichiro Kamatani,Stéphanie Debette,Martin Dichgans +170 more
TL;DR: A multiancestry genome-wide-association meta-analysis and discovered 22 new stroke risk loci, indicating mechanisms not previously implicated in stroke pathophysiology, with prioritization of risk variants and genes accomplished through bioinformatics analyses using extensive functional datasets.
Journal ArticleDOI
Loci associated with ischaemic stroke and its subtypes (SiGN) : A genome-wide association study
Sara L. Pulit,Patrick F. McArdle,Quenna Wong,Rainer Malik,Katrina Gwinn,Sefanja Achterberg,Ale Algra,Philippe Amouyel,Christopher D. Anderson,Donna K. Arnett,Ethem Murat Arsava,John Attia,Hakan Ay,Traci M. Bartz,Thomas W.K. Battey,Oscar R. Benavente,Steve Bevan,Alessandro Biffi,Joshua C. Bis,Susan H. Blanton,Giorgio B. Boncoraglio,Robert D. Brown,Annette I. Burgess,Caty Carrera,Sherita N Chapman Smith,Daniel I. Chasman,Ganesh Chauhan,Wei-Min Chen,Yu-Ching Cheng,Michael Chong,Lisa Cloonan,John W. Cole,Ioana Cotlarciuc,Carlos Cruchaga,Elisa Cuadrado-Godia,Tushar Dave,Jesse Dawson,Stéphanie Debette,Hossein Delavaran,Cameron A Dell,Martin Dichgans,Kimberly F. Doheny,Chuanhui Dong,David Duggan,Gunnar Engström,Michele K. Evans,Xavier Estivill Pallejà,Jessica D. Faul,Israel Fernandez-Cadenas,Myriam Fornage,Philippe M. Frossard,Karen L. Furie,Dale M Gamble,Christian Gieger,Anne-Katrin Giese,Eva Giralt-Steinhauer,Hector M. González,An Goris,Solveig Gretarsdottir,Raji P. Grewal,Ulrike Grittner,Stefan Gustafsson,Buhm Han,Graeme J. Hankey,Laura Heitsch,Peter Higgins,Marc C. Hochberg,Elizabeth G. Holliday,Jemma C. Hopewell,Richard B. Horenstein,George Howard,M. Arfan Ikram,Andreea Ilinca,Erik Ingelsson,Marguerite R. Irvin,Rebecca D. Jackson,Christina Jern,Jordi Jimenez Conde,Julie A. Johnson,Katarina Jood,Muhammad S Kahn,Robert C. Kaplan,L. Jaap Kappelle,Sharon L.R. Kardia,Keith L. Keene,Brett M. Kissela,Dawn Kleindorfer,Simon A. Koblar,Daniel L. Labovitz,Lenore J. Launer,Cathy C. Laurie,Cecelia A. Laurie,Cue Hyunkyu Lee,Jin-Moo Lee,Manuel Lehm,Robin Lemmens,Christopher Levi,Didier Leys,Arne Lindgren,W. T. Longstreth,Jane Maguire,Ani Manichaikul,Hugh S. Markus,Leslie A. McClure,Caitrin W. McDonough,Christa Meisinger,Olle Melander,James F. Meschia,Marina Mola-Caminal,Joan Montaner,Thomas H. Mosley,Martina Müller-Nurasyid,Mike A. Nalls,Jeffrey R. O'Connell,Martin O'Donnell,Angel Ois,George J. Papanicolaou,Guillaume Paré,Leema Reddy Peddareddygari,Annie Pedersen,Joanna Pera,Annette Peters,D Poole,Bruce M. Psaty,Raquel Rabionet,Miriam R. Raffeld,Kristiina Rannikmäe,Asif Rasheed,Petra Redfors,Alexander P. Reiner,Kathryn M. Rexrode,Marta Ribasés,Stephen S. Rich,Wim Robberecht,Ana Rodríguez-Campello,Arndt Rolfs,Jaume Roquer,Lynda M. Rose,Daniel Rosenbaum,Natalia S. Rost,Peter M. Rothwell,Tatjana Rundek,Kathleen A. Ryan,Ralph L. Sacco,Michèle M. Sale,Danish Saleheen,Veikko Salomaa,Cristina Sánchez-Mora,Carsten Oliver Schmidt,Helena Schmidt,Reinhold E. Schmidt,Markus Schürks,Rodney J. Scott,Helen Segal,Stephan Seiler,Sudha Seshadri,Pankaj Sharma,Alan R. Shuldiner,Brian Silver,Agnieszka Slowik,Jennifer A. Smith,Martin Söderholm,Carolina Soriano,Mary J. Sparks,Tara M. Stanne,Kari Stefansson,O. Colin Stine,Konstantin Strauch,Jonathan Sturm,Cathie Sudlow,Salman M. Tajuddin,Robert L. Talbert,Turgut Tatlisumak,Vincent Thijs,Gudmar Thorleifsson,Unnur Thorsteindottir,Steffen Tiedt,Matthew Traylor,Stella Trompet,Valerie Valant,Melanie Waldenberger,Matthew Walters,Liyong Wang,Sylvia Wassertheil-Smoller,David R. Weir,Kerri L. Wiggins,Stephen R. Williams,Dorota Wloch-Kopec,Daniel Woo,Rebecca Woodfield,Ona Wu,Huichun Xu,Alan B. Zonderman,Bradford B. Worrall,Paul I.W. de Bakker,Steven J. Kittner,Braxton D. Mitchell,Jonathan Rosand,Cathie L. M. Sudlow,Bradford B. Worrall,Donna K. Arnett,Oscar R. Benavente,Sylvia Wasssertheil-Smoller +202 more
TL;DR: A novel locus (G allele at rs12122341) at 1p13.2 near TSPAN2 that was associated with large artery atherosclerosis-related stroke was identified and supported robust associations with ischaemic stroke for four other loci that have been reported in previous studies.
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Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies
Ganesh Chauhan,Corey R. Arnold,Audrey Y. Chu,Myriam Fornage,Azadeh Reyahi,Joshua C. Bis,Aki S. Havulinna,Muralidharan Sargurupremraj,Albert V. Smith,Hieab H.H. Adams,Seung Hoan Choi,Sara L. Pulit,Stella Trompet,Melissa E. Garcia,Ani Manichaikul,Alexander Teumer,Stefan Gustafsson,Traci M. Bartz,Céline Bellenguez,Jean-Sébastien Vidal,Xueqiu Jian,Olafur Kjartansson,Kerri L. Wiggins,Claudia L. Satizabal,Flora Xue,Samuli Ripatti,Yongmei Liu,Joris Deelen,Marcel den Hoed,Steve Bevan,Jemma C. Hopewell,Rainer Malik,Susan R. Heckbert,Kenneth Rice,Nicholas L. Smith,Christopher R Levi,Pankaj Sharma,Cathie Sudlow,Ali Moussavi Nik,John W. Cole,Reinhold E. Schmidt,James F. Meschia,Vincent Thijs,Arne Lindgren,Olle Melander,Raji P. Grewal,Ralph L. Sacco,Tatjana Rundek,Peter M. Rothwell,Donna K. Arnett,Christina Jern,Julie A. Johnson,Oscar R. Benavente,Sylvia Wassertheil-Smoller,Jin-Moo Lee,Quenna Wong,Hugo J. Aparicio,Stefan T. Engelter,Manja Kloss,Didier Leys,Alessandro Pezzini,Julie E. Buring,Paul M. Ridker,Claudine Berr,Jean-François Dartigues,Anders Hamsten,Patrik K. E. Magnusson,Matthew Traylor,Nancy L. Pedersen,Lars Lannfelt,Lars Lindgren,Cecilia M. Lindgren,Andrew P. Morris,Jordi Jimenez-Conde,Joan Montaner,Farid Radmanesh,Agnieszka Slowik,Daniel Woo,Albert Hofman,Peter J. Koudstaal,Marileen L.P. Portegies,André G. Uitterlinden,Anton J. M. de Craen,Ian Ford,J. Wouter Jukema,David J. Stott,Norrina B. Allen,Michèle M. Sale,Andrew D. Johnson,David A. Bennett,Philip L. De Jager,Charles C. White,Hans J. Grabe,Marcello Ricardo Paulista Markus,Ulf Schminke,Giorgio B. Boncoraglio,Robert Clarke,Yoichiro Kamatani,Jean Dallongeville,Oscar L. Lopez,Jerome I. Rotter,Mike A. Nalls,Rebecca F. Gottesman,Michael Griswold,David S. Knopman,B. Gwen Windham,Alexa S. Beiser,Hugh S. Markus,Erkki Vartiainen,Curtis R. French,Martin Dichgans,Tomi Pastinen,Mark Lathrop,Vilmundur Gudnason,Tobias Kurth,Bruce M. Psaty,Tamara B. Harris,Stephen S. Rich,Anita L. DeStefano,Carsten Oliver Schmidt,Bradford B. Worrall,Jonathan Rosand,Veikko Salomaa,Thomas H. Mosley,Erik Ingelsson,Cornelia M. van Duijn,Christophe Tzourio,Kathryn M. Rexrode,Ordan J. Lehmann,Lenore J. Launer,M. Arfan Ikram,Peter Carlsson,Daniel I. Chasman,Sarah J. Childs,William T. Longstreth,Sudha Seshadri,Stéphanie Debette +136 more
TL;DR: Empirical and experimental data suggest that FOXF2 mediates this association, potentially via differentiation defects of cerebral vascular mural cells, and further expression studies in appropriate human tissues are needed to fully understand the underlying mechanisms.
Journal ArticleDOI
X-Linked Dominant Scapuloperoneal Myopathy Is Due to a Mutation in the Gene Encoding Four-and-a-Half-LIM Protein 1
Catarina M. Quinzii,Tuan Vu,K. Christopher Min,Kurenai Tanji,Sandra Barral,Raji P. Grewal,Andrea Kattah,Pilir Camaño,David Otaegui,Teruhito Kunimatsu,David M. Blake,Kirk C. Wilhelmsen,Kirk C. Wilhelmsen,Lewis P. Rowland,Arthur P. Hays,Eduardo Bonilla,Michio Hirano +16 more
TL;DR: This is the first report, to the authors' knowledge, of X-linked dominant SP myopathy and the first human mutation in FHL1, which may contribute to stability of sarcomeres and sarcolemma, myofibrillary assembly, and transcriptional regulation.
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Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies.
Matthew Traylor,Elodie Persyn,Liisa Tomppo,Sofia Klasson,Vida Abedi,Mark K Bakker,Nuria Torres,Linxin Li,Steven Bell,Loes Rutten-Jacobs,D Tozer,Christoph J. Griessenauer,Yanfei Zhang,Annie Pedersen,Pankaj Sharma,Jordi Jimenez-Conde,Tatjana Rundek,Raji P. Grewal,Arne Lindgren,James F. Meschia,Veikko Salomaa,Aki S. Havulinna,Christina Kourkoulis,Katherine Crawford,Sandro Marini,Braxton D. Mitchell,Steven J. Kittner,Jonathan Rosand,Martin Dichgans,Christina Jern,Daniel Strbian,Israel Fernandez-Cadenas,Ramin Zand,Ynte M. Ruigrok,Natalia S. Rost,Robin Lemmens,Peter M. Rothwell,Christopher D. Anderson,Joanna M. Wardlaw,Cathryn M. Lewis,Hugh S. Markus,UK Dna Lacunar Stroke Study Investigators +41 more
TL;DR: In this paper, a pooled analysis of data from newly recruited patients with an MRI-confirmed diagnosis of lacunar stroke and existing genome-wide association studies (GWAS) was performed to identify novel associations and provide mechanistic insights into the disease.