D
Dachuan Dong
Researcher at Stanford University
Publications - 7
Citations - 71
Dachuan Dong is an academic researcher from Stanford University. The author has contributed to research in topics: Adrenal gland & Hormone. The author has an hindex of 4, co-authored 7 publications receiving 34 citations. Previous affiliations of Dachuan Dong include VA Palo Alto Healthcare System & Veterans Health Administration.
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Journal ArticleDOI
The role of miRNAs in regulating adrenal and gonadal steroidogenesis
Salman Azhar,Dachuan Dong,Dachuan Dong,Wen-Jun Shen,Wen-Jun Shen,Zhigang Hu,Fredric B. Kraemer,Fredric B. Kraemer +7 more
TL;DR: The recent advances in miRNA-mediated regulation of steroidogenesis with emphasis on adrenal and gonadal steroidogenesis are summarized.
Journal ArticleDOI
Tissue-Specific Ablation of ACSL4 Results in Disturbed Steroidogenesis.
Wei Wang,Wei Wang,Xiao Hao,Xiao Hao,Lina Han,Lina Han,Zhe Yan,Zhe Yan,Wen-Jun Shen,Wen-Jun Shen,Dachuan Dong,Dachuan Dong,Kathrin B. Hasbargen,Kathrin B. Hasbargen,Stefanie Bittner,Yuan Cortez,Yuan Cortez,Andrew S. Greenberg,Salman Azhar,Salman Azhar,Fredric B. Kraemer,Fredric B. Kraemer +21 more
TL;DR: It is concluded that ACSL4 is dispensable for normal steroidogenesis, with effects on steroid production appear due to reductions in cholesteryl ester stores rather than disturbances of signaling pathways.
Journal ArticleDOI
Creosote bush-derived NDGA attenuates molecular and pathological changes in a novel mouse model of non-alcoholic steatohepatitis (NASH).
Lu Han,Stefanie Bittner,Dachuan Dong,Yuan Cortez,Hunter Dulay,Sara Arshad,Wen-Jun Shen,Wen-Jun Shen,Fredric B. Kraemer,Salman Azhar,Salman Azhar +10 more
TL;DR: In conclusion, NDGA exerts anti-NASH/anti-fibrotic actions and raises the therapeutic potential of NDGA for treatment of NASH patients with fibrosis and other associated complications.
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Molecular changes in hepatic metabolism in ZDSD rats-A new polygenic rodent model of obesity, metabolic syndrome, and diabetes.
Lu Han,Stefanie Bittner,Dachuan Dong,Yuan Cortez,Alex Bittner,Jackie Chan,Meenakshi Umar,Wen-Jun Shen,Wen-Jun Shen,Richard G. Peterson,Fredric B. Kraemer,Salman Azhar,Salman Azhar +12 more
TL;DR: Elevated levels of ER stress markers correlated with the dysregulation of hepatic lipid metabolism in ZDSD rats and key proteins participating in unfolded protein response pathways were also upregulated and likely contribute to the pathogenesis of dyslipidemia and insulin resistance.
Journal ArticleDOI
Plasma membrane cholesterol trafficking in steroidogenesis.
Bing Deng,Wen-Jun Shen,Wen-Jun Shen,Dachuan Dong,Dachuan Dong,Salman Azhar,Salman Azhar,Fredric B. Kraemer,Fredric B. Kraemer +8 more
TL;DR: Results indicate that STX5 and α‐SNAP facilitate cholesterol trafficking from PMs to mitochondria for adrenal steroid synthesis and underscore the importance of vesicular trafficking of PM cholesterol for steroidogenesis.