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Andrew S. Greenberg
Researcher at Tufts University
Publications - 197
Citations - 27474
Andrew S. Greenberg is an academic researcher from Tufts University. The author has contributed to research in topics: Adipose tissue & Perilipin. The author has an hindex of 74, co-authored 191 publications receiving 25437 citations. Previous affiliations of Andrew S. Greenberg include University of California, San Francisco & Yale University.
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Journal ArticleDOI
Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
Saverio Cinti,Grant A. Mitchell,Giorgio Barbatelli,Incoronata Murano,Enzo Ceresi,Emanuela Faloia,Shupei Wang,Mélanie Fortier,Andrew S. Greenberg,Martin S. Obin +9 more
TL;DR: It is demonstrated that >90% of all macrophages in WAT of obese mice and humans are localized to dead adipocytes, where they fuse to form syncytia that sequester and scavenge the residual “free” adipocyte lipid droplet and ultimately form multinucleate giant cells, a hallmark of chronic inflammation.
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Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid.
TL;DR: These data show for the first time that substantial quantities of IL-6 (up to 75 ng/mL) accumulate in the medium during incubations of both adipocytes and adipose tissue.
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Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial.
Steven B. Heymsfield,Andrew S. Greenberg,Ken Fujioka,Russell M. Dixon,Robert F. Kushner,Thomas K. Hunt,John A. Lubina,Janet Patane,Barbara Self,P Hunt,Mark A. Mccamish +10 more
TL;DR: Administration of exogenous leptin appears to induce weight loss in some obese subjects with elevated endogenous serum leptin concentrations and a dose-response relationship with weight and fat loss was observed with subcutaneous recombinant leptin injections in both lean and obese subjects.
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Obesity and the role of adipose tissue in inflammation and metabolism
TL;DR: Understanding of the adipocyte as an endocrine organ is leading to new insights into obesity and health, and exercise activates the AMP-activated protein kinase (AMPK) in muscle and other tissues, a pathway that increases fat oxidation and glucose transport.
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Effect of Rosiglitazone Treatment on Nontraditional Markers of Cardiovascular Disease in Patients With Type 2 Diabetes Mellitus
Steven M. Haffner,Andrew S. Greenberg,Wayde M. Weston,Hongzi Chen,Kenneth R. Williams,Martin I. Freed +5 more
TL;DR: Rosiglitazone reduces serum levels of MMP-9 and the proinflammatory marker CRP in patients with type 2 diabetes, which indicates potentially beneficial effects on overall cardiovascular risk.