Daesung Lee

TL;DR: Two pairs of complexity-generating reactions with an essential product-substrate relationship along a synthetic pathway are demonstrated, illustrating a key element in a planning algorithm for diversity-oriented synthesis.

TL;DR: An imaging method that allows simultaneous in situ quantification of cholesterol in two leaflets of the plasma membrane (PM) using tunable orthogonal cholesterol sensors found excellent correlation between the IPM cholesterol level and cellular Wnt signaling activity, suggesting that TAPMC and stimulus-induced PM cholesterol redistribution are crucial for tight regulation of cellular processes under physiological conditions.

TL;DR: In this article, the addition of fluorine-containing nucleophiles onto aryne intermediates was efficiently promoted by either silver catalysts or silver-containing stoichiometric reagents.