D
Daisuke Goto
Researcher at University of Tsukuba
Publications - 98
Citations - 3177
Daisuke Goto is an academic researcher from University of Tsukuba. The author has contributed to research in topics: Arthritis & Antibody. The author has an hindex of 30, co-authored 95 publications receiving 2964 citations. Previous affiliations of Daisuke Goto include Japan Society for the Promotion of Science.
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Journal ArticleDOI
c-myc Is a Downstream Target of the Smad Pathway
Ken Yagi,Masao Furuhashi,Hiromasa Aoki,Daisuke Goto,Hiroyuki Kuwano,Kazuo Sugamura,Kohei Miyazono,Kohei Miyazono,Mitsuyasu Kato +8 more
TL;DR: TGF-β signaling may suppress c-myc promoter activity by dissociating p300 from E2F-4, which is a critical event for growth inhibition induced by transforming growth factor-β and frequently impaired in cancer cells.
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Alternatively Spliced Variant of Smad2 Lacking Exon 3 COMPARISON WITH WILD-TYPE Smad2 AND Smad3
TL;DR: The results suggest that exon 3 of Smad2 interferes with the direct DNA binding ofSmad2, and modifies the function of SmAd2 in transcription of certain target genes.
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Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase.
Keiichi Iwanami,Isao Matsumoto,Isao Matsumoto,Yoko Tanaka-Watanabe,Asuka Inoue,Masahiko Mihara,Yoshiyuki Ohsugi,Mizuko Mamura,Daisuke Goto,Satoshi Ito,Akito Tsutsumi,Tadamitsu Kishimoto,Takayuki Sumida +12 more
TL;DR: It is proposed that the IL-6/IL-17 axis might also be involved in the generation of RA, especially in the early effector phase.
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Laser microdissection-based analysis of cytokine balance in the kidneys of patients with lupus nephritis.
Y Wang,Satoshi Ito,Yusuke Chino,Daisuke Goto,Isao Matsumoto,Hideyuki Murata,Akito Tsutsumi,Taichi Hayashi,Kazuhiko Uchida,J Usui,Kunihiro Yamagata,Takayuki Sumida +11 more
TL;DR: The expression level of IL‐17 was correlated closely with clinical parameters such as haematuria, blood urea nitrogen level, SLE Disease Activity Index scores in both glomersuli and interstitium, urine protein level in glomeruli and serum creatinine and Creatinine clearance levels in interst itium, which suggests that IL‐ 17 might play a critical role in SLE development.
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Anti-interleukin-6 receptor antibody (tocilizumab) treatment of multicentric Castleman's disease.
Masashi Matsuyama,Takeshi Suzuki,Hiroto Tsuboi,Satoshi Ito,Mizuko Mamura,Daisuke Goto,Isao Matsumoto,Akito Tsutsumi,Takayuki Sumida +8 more
TL;DR: In each case, tocilizumab alleviated symptoms, including generalized fatigue, pyrexia, and alleviated biochemical abnormalities, including anemia, hypoalbuminemia, hypergammaglobulinemi, and increased C-reactive protein (CRP).