D
Dale Ando
Researcher at Sangamo BioSciences
Publications - 30
Citations - 2986
Dale Ando is an academic researcher from Sangamo BioSciences. The author has contributed to research in topics: Zinc finger nuclease & Zinc finger. The author has an hindex of 11, co-authored 30 publications receiving 2796 citations. Previous affiliations of Dale Ando include Vita-Salute San Raffaele University & City of Hope National Medical Center.
Papers
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Journal ArticleDOI
Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases
Elena E. Perez,Jianbin Wang,Jeffrey C. Miller,Yann Jouvenot,Yann Jouvenot,Kenneth Kim,Olga Liu,Nathaniel Wang,Gary Lee,Victor Bartsevich,Ya Li Lee,Dmitry Guschin,Igor Rupniewski,Adam James Waite,Carmine Carpenito,Richard G. Carroll,Jordan S. Orange,Fyodor D. Urnov,Edward J. Rebar,Dale Ando,Philip D. Gregory,James L. Riley,Michael C. Holmes,Carl H. June +23 more
TL;DR: O adoptive transfer of ex vivo expanded CCR5 ZFN–modified autologous CD4+ T cells in HIV patients is an attractive approach for the treatment of HIV-1 infection.
Journal ArticleDOI
Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery
Angelo Lombardo,Angelo Lombardo,Pietro Genovese,Christian Beauséjour,Silvia Colleoni,Silvia Colleoni,Ya Li Lee,Kenneth Kim,Dale Ando,Fyodor D. Urnov,Cesare Galli,Philip D. Gregory,Michael C. Holmes,Luigi Naldini +13 more
TL;DR: Using IDLV delivery and ZFNs targeting distinct loci, high levels of gene addition are observed in a panel of human cell lines, as well as human embryonic stem cells, allowing rapid, selection-free isolation of clonogenic cells with the desired genetic modification.
Journal ArticleDOI
Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery
Angelo Lombardo,Angelo Lombardo,Pietro Genovese,Pietro Genovese,Christian Beauséjour,Christian Beauséjour,Silvia Colleoni,Silvia Colleoni,Ya Li Lee,Ya Li Lee,Kenneth Kim,Kenneth Kim,Dale Ando,Dale Ando,Fyodor D. Urnov,Fyodor D. Urnov,Cesare Galli,Cesare Galli,Philip D. Gregory,Philip D. Gregory,Michael C. Holmes,Michael C. Holmes,Luigi Naldini,Luigi Naldini +23 more
TL;DR: This paper exploited the infectivity of integrase-defective lentiviral vectors (IDLV) to express ZFNs and provide the template DNA for gene correction in different cell types.
Patent
Methods and compositions for gene inactivation
TL;DR: In this article, methods and compositions for inactivating CCR-5 genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain.
Journal ArticleDOI
Efficient clinical scale gene modification via zinc finger nuclease-targeted disruption of the HIV co-receptor CCR5.
Dawn A. Maier,Andrea L. Brennan,Shuguang Jiang,Gwendolyn Binder-Scholl,Gary Lee,Gabriela Plesa,Zhaohui Zheng,Julio Cotte,Carmine Carpenito,Travis Wood,S. Kaye Spratt,Dale Ando,Philip D. Gregory,Michael C. Holmes,Elena E. Perez,James L. Riley,Richard G. Carroll,Carl H. June,Bruce L. Levine +18 more
TL;DR: Modifications to the laboratory scale process, incorporating clinically compatible reagents and methods, resulted in a robust ex vivo manufacturing process capable of generating >10(10) CCR5 gene-edited CD4+ T cells from healthy and HIV+ donors.