F
Fyodor D. Urnov
Researcher at University of California, Berkeley
Publications - 167
Citations - 26698
Fyodor D. Urnov is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Zinc finger nuclease & Gene. The author has an hindex of 62, co-authored 167 publications receiving 24777 citations. Previous affiliations of Fyodor D. Urnov include Vita-Salute San Raffaele University & University of California.
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Journal ArticleDOI
A TALE nuclease architecture for efficient genome editing
Jeffrey C. Miller,Siyuan Tan,Guijuan Qiao,Kyle A. Barlow,Jianbin Wang,Danny F Xia,Xiangdong Meng,David Paschon,Elo Leung,Sarah J. Hinkley,Gladys P Dulay,Kevin Hua,Irina Ankoudinova,Gregory J. Cost,Fyodor D. Urnov,H. Steve Zhang,Michael C. Holmes,Lei Zhang,Philip D. Gregory,Edward J. Rebar +19 more
TL;DR: This study identifies TALE truncation variants that efficiently cleave DNA when linked to the catalytic domain of FokI and uses them to generate discrete edits or small deletions within endogenous human NTF3 and CCR5 genes at efficiencies of up to 25%.
Journal ArticleDOI
Genome editing with engineered zinc finger nucleases
TL;DR: A broad range of outcomes has resulted from the application of the same core technology: targeted genome cleavage by engineered, sequence-specific zinc finger nucleases followed by gene modification during subsequent repair.
Journal ArticleDOI
Highly efficient endogenous human gene correction using designed zinc-finger nucleases
Fyodor D. Urnov,Jeffrey C. Miller,Ya-Li Lee,Christian Beauséjour,Jeremy M. Rock,Sheldon Augustus,Andrew C. Jamieson,Matthew H. Porteus,Philip D. Gregory,Michael C. Holmes +9 more
TL;DR: It is shown that zinc-finger nucleases designed against an X-linked severe combined immune deficiency mutation in the IL2Rγ gene yielded more than 18% gene-modified human cells without selection, raising the possibility of strategies based on zinc- finger nucleases for the treatment of disease.
Journal ArticleDOI
Genetic engineering of human pluripotent cells using TALE nucleases
Dirk Hockemeyer,Haoyi Wang,Samira Kiani,Christine S. Lai,Qing Gao,John P. Cassady,Gregory J. Cost,Lei Zhang,Yolanda Santiago,Jeffrey C. Miller,Bryan Zeitler,Jennifer M. Cherone,Xiangdong Meng,Sarah J. Hinkley,Edward J. Rebar,Philip D. Gregory,Fyodor D. Urnov,Rudolf Jaenisch +17 more
TL;DR: In this article, the authors used transcription activator-like effector nucleases (TALENs) for site-specific genome modification in human pluripotent cells with similar efficiency and precision as do zinc-finger nucleases.
Journal ArticleDOI
Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases
Elena E. Perez,Jianbin Wang,Jeffrey C. Miller,Yann Jouvenot,Yann Jouvenot,Kenneth Kim,Olga Liu,Nathaniel Wang,Gary Lee,Victor Bartsevich,Ya Li Lee,Dmitry Guschin,Igor Rupniewski,Adam James Waite,Carmine Carpenito,Richard G. Carroll,Jordan S. Orange,Fyodor D. Urnov,Edward J. Rebar,Dale Ando,Philip D. Gregory,James L. Riley,Michael C. Holmes,Carl H. June +23 more
TL;DR: O adoptive transfer of ex vivo expanded CCR5 ZFN–modified autologous CD4+ T cells in HIV patients is an attractive approach for the treatment of HIV-1 infection.