Dan Grandér

TL;DR: The extent of interspecies conservation among different lncRNAs is reviewed, with a focus on a subset of lnc RNAs that have been functionally investigated, and several examples of l NCRNAs where RNA structure appears to be the main functional unit and evolutionary constraint.

TL;DR: This study is the first comprehensive screen of FBXW7 mutations in various human malignancies and shows that FBxW7 is a general tumor suppressor in human cancer.

TL;DR: A previously unidentified PTENpg1-encoded antisense RNA (asRNA), which regulates PTEN transcription and PTEN mRNA stability, is characterized and disruption of this asRNA-regulated network induces cell-cycle arrest and sensitizes cells to doxorubicin, which suggests a biological function for the respective PTENPG1 expressed asRNAs.

TL;DR: The LUMA assay may provide a useful method to analyze genome-wide DNA methylation for a variety of physiological and pathological conditions including etiologic, diagnostic and prognostic aspects of cancer.

TL;DR: It is found that apoptosis induced by IFN α was associated with activation of caspases-1, -2, -3, -8 and -9 and that this activation was a critical event in IFNα-induced caspase cascade.