S
Sophia Apostolidou
Researcher at University College London
Publications - 44
Citations - 2844
Sophia Apostolidou is an academic researcher from University College London. The author has contributed to research in topics: Cancer & DNA methylation. The author has an hindex of 17, co-authored 41 publications receiving 2441 citations. Previous affiliations of Sophia Apostolidou include University College London Hospitals NHS Foundation Trust.
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Journal ArticleDOI
Ovarian cancer screening and mortality in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial.
Ian Jacobs,Ian Jacobs,Ian Jacobs,Usha Menon,Andy Ryan,Aleksandra Gentry-Maharaj,Matthew Burnell,Jatinderpal Kalsi,Nazar Najib Amso,Sophia Apostolidou,Elizabeth Benjamin,Derek Cruickshank,Danielle N. Crump,Susan K Davies,Anne Dawnay,Stephen Dobbs,Gwendolen Fletcher,Jeremy Ford,Jeremy Ford,Keith M. Godfrey,Richard Gunu,Mariam Habib,Mariam Habib,Rachel Hallett,Rachel Hallett,Jonathan Herod,Howard Jenkins,Chloe Karpinskyj,Simon Leeson,Sara Lewis,William R. Liston,Alberto Lopes,Tim Mould,Tim Mould,John Murdoch,David H. Oram,Dustin J. Rabideau,K. Reynolds,Ian Scott,Mourad W. Seif,Mourad W. Seif,A. Sharma,A. Sharma,Naveena Singh,Julie Taylor,Fiona Warburton,Fiona Warburton,Martin Widschwendter,Karin Williamson,Robert Woolas,Robert Woolas,Lesley Fallowfield,Alistair McGuire,Stuart Campbell,Mahesh K. B. Parmar,Steven J. Skates +55 more
TL;DR: Although the mortality reduction was not significant in the primary analysis, it was noted a significant mortality reduction with MMS when prevalent cases were excluded, and encouraging evidence of a mortality reduction in years 7–14 was noted.
Journal ArticleDOI
FBXW7/hCDC4 is a general tumor suppressor in human cancer
Shahab Akhoondi,Dahui Sun,Natalie von der Lehr,Sophia Apostolidou,Kathleen Klotz,Alena Maljukova,Diana Cepeda,Heidi Fiegl,Dimitra Dofou,Christian Marth,Elisabeth Mueller-Holzner,Martin Corcoran,Markus Dagnell,Sepideh Zabihi Nejad,Babak Noori Nayer,Mohammad Reza Zali,Johan Hansson,Susanne Egyhazi,Fredrik Petersson,Per Sangfelt,Hans Nordgren,Dan Grandér,Steven I. Reed,Martin Widschwendter,Olle Sangfelt,Charles Spruck +25 more
TL;DR: This study is the first comprehensive screen of FBXW7 mutations in various human malignancies and shows that FBxW7 is a general tumor suppressor in human cancer.
Journal ArticleDOI
An epigenetic signature in peripheral blood predicts active ovarian cancer.
Andrew E. Teschendorff,Usha Menon,Aleksandra Gentry-Maharaj,Susan J. Ramus,Simon A. Gayther,Sophia Apostolidou,Allison Jones,Matthias Lechner,Stephan Beck,Ian Jacobs,Martin Widschwendter +10 more
TL;DR: The results underscore the potential of DNAm profiling in peripheral blood as a tool for detection or risk-prediction of epithelial cancers, and warrants further in-depth and higher CpG coverage studies to further elucidate this role.
Journal ArticleDOI
Risk Algorithm Using Serial Biomarker Measurements Doubles the Number of Screen-Detected Cancers Compared With a Single-Threshold Rule in the United Kingdom Collaborative Trial of Ovarian Cancer Screening
Usha Menon,Andy Ryan,J Kalsi,Aleksandra Gentry-Maharaj,Anne Dawnay,Mariam Habib,Sophia Apostolidou,Naveena Singh,Elizabeth Benjamin,M Burnell,Susan K Davies,A. Sharma,Richard Gunu,K. A. Godfrey,Alberto Lopes,David Oram,Jonathan Herod,Karin Williamson,Mourad W. Seif,Howard Jenkins,Tim Mould,Robert Woolas,John Murdoch,Stephen Dobbs,Nazar Najib Amso,Simon Leeson,Derek Cruickshank,Ian Scott,Lesley Fallowfield,Martin Widschwendter,K. Reynolds,Alistair McGuire,Stuart Campbell,Mahesh M K Parmar,Steven J. Skates,Ian Jacobs,Ian Jacobs +36 more
TL;DR: Screening by using ROCA doubled the number of screen-detected iEOCs compared with a fixed cutoff, suggesting reliance on predefined single-threshold rules may result in biomarkers of value being discarded in the context of cancer screening.
Journal ArticleDOI
Epigenotyping in Peripheral Blood Cell DNA and Breast Cancer Risk: A Proof of Principle Study
Martin Widschwendter,Sophia Apostolidou,Elke Raum,Dietrich Rothenbacher,Heidi Fiegl,Usha Menon,Christa Stegmaier,Ian Jacobs,Hermann Brenner +8 more
TL;DR: This first large-scale epigenotyping study demonstrates that DNA methylation may serve as a link between the environment and the genome to predict the risk of developing chronic diseases with sufficient accuracy to guide preventive measures.